DFFA / ICAD / DFF45

DNA fragmentation factor, 45kDa, alpha polypeptide

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human 45 kD DNA fragmentation factor (DFF45) was identified recently that was cleaved by caspase-3 during apoptosis. Mouse homologue of human DFF45 was identified as a DNase inhibitor designated ICAD. DFF45/ICAD have short forms that were termed DFF35 and ICADs, respectively. Upon cleavage of DFF45/ICAD, the caspase activated deoxyribonuclease (DFF40/CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of DFF45/ICAD, which causes DFF40/CAD activation and DNA degradation, is the hallmark of apoptotic cell death.

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Antibodies (81)

Proteins (15)

ELISA Kits (1)

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Primary (81)

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Target

DFFA / ICAD / DFF45 (97)

Reactivity

Human (76)

Mouse (23)

Rat (8)

Dog (3)

Gibbon (3)

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Orangutan (3)

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monoclonal mc (10)

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Source

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Low endotoxin level (2)

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IHC-plus™ DFFA / ICAD / DFF45 Antibody LS-B14741

(4.0) Rating

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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IHC-plus™ DFFA / ICAD / DFF45 Antibody LS-B14742

(4.0) Rating

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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IHC-plus™ DFFA / ICAD / DFF45 Antibody LS-B558

(4.0) Rating

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ DFFA / ICAD / DFF45 Antibody LS-B3186

(4.0) Rating

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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DFFA / ICAD / DFF45 Antibody LS-C348943

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539

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DFFA / ICAD / DFF45 Antibody (Internal) LS-C352123

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$299

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DFFA / ICAD / DFF45 Antibody (aa1-331) LS-C375596

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal (aa1-331) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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DFFA / ICAD / DFF45 Antibody LS-C752442

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$351

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DFFA / ICAD / DFF45 Antibody (120-200 aa, Internal) LS-C384058

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal (120-200 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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DFFA / ICAD / DFF45 Antibody (Gln177) LS-C176879

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal (Gln177) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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Mouse DFFA / ICAD / DFF45 Protein (Recombinant His-T7) (aa19-262) - LS-G26103

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.7 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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DFFA / ICAD / DFF45 Antibody (aa271-331) LS-C286535

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal (aa271-331) Antibody

Reactivity:

Human

Applications:

IF, IHC

Format:

Unconjugated

Price:

1 µg/$295; 100 µl/$532

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DFFA / ICAD / DFF45 Antibody (aa151-200) LS-C119544

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal (aa151-200) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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DFFA / ICAD / DFF45 Antibody (clone OTI1B10) LS-C114352

Antibody:

DFFA / ICAD / DFF45 Mouse anti-Human Monoclonal (OTI1B10) Antibody

Applications:

IF, WB

Format:

Unconjugated

Price:

100 µl/$434

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DFFA / ICAD / DFF45 Antibody (aa1-331, clone OTI1B10, Carrier-free) LS-C784086

Antibody:

DFFA / ICAD / DFF45 Mouse anti-Human Monoclonal (aa1-331) (Carrier-free) (OTI1B10) Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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DFFA / ICAD / DFF45 Antibody (clone OTI5C4) LS-C114353

Antibody:

DFFA / ICAD / DFF45 Mouse anti-Human Monoclonal (OTI5C4) Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

100 µl/$434

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DFFA / ICAD / DFF45 Antibody (clone OTI5C4, Carrier-free) LS-C784088

Antibody:

DFFA / ICAD / DFF45 Mouse anti-Human Monoclonal (Carrier-free) (OTI5C4) Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

DFFA / ICAD / DFF45 Antibody (clone OTI3F12) LS-C114354

Antibody:

DFFA / ICAD / DFF45 Mouse anti-Human Monoclonal (OTI3F12) Antibody

Reactivity:

Human, Monkey

Applications:

IF, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

DFFA / ICAD / DFF45 Antibody (clone OTI3F12, Carrier-free) LS-C784089

Antibody:

DFFA / ICAD / DFF45 Mouse anti-Human Monoclonal (Carrier-free) (OTI3F12) Antibody

Reactivity:

Human, Monkey

Applications:

IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

DFFA / ICAD / DFF45 Antibody (150-230 aa, Internal) LS-C380500

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal (150-230 aa, Internal) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

DFFA / ICAD / DFF45 Antibody LS-C823591

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

DFFA / ICAD / DFF45 Antibody LS-C153031

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µg/$522

Select

DFFA / ICAD / DFF45 Antibody LS-C747531

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

DFFA / ICAD / DFF45 Antibody (aa271-331) LS-C288218

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal (aa271-331) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

DFFA / ICAD / DFF45 Antibody LS-C806931

Antibody:

DFFA / ICAD / DFF45 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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