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Anti-Delta3 / DLL3 Antibody (aa222-234) LS-C187442


Wt. Vol. Conc. Price
100 µg - 1 mg/ml $340
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular Delta3 / DLL3 Antibodies

Anti-Delta3 / DLL3 Antibody (aa100-150) LS-C148700
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Western blot Image
Anti-Delta3 / DLL3 Antibody (aa545-573) LS-C167439
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Anti-Delta3 / DLL3 Antibody (aa519-548) IHC-plus™ LS-B10548
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100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Mouse Delta3 / DLL3
Mouse, Rat
Western blot, ELISA


Mouse Delta3 / DLL3
Mouse, Rat (tested or 100% immunogen sequence identity)
Hamster (at least 90% immunogen sequence identity)
IgG Polyclonal


  • Western blot (1:100 - 1:500)

Specificity and Use

Delta3 / DLL3 antibody was raised against keyhole Limpet Hemocyanin (KLH) conjugated peptide sequence CSPEHGYCEEPDE, corresponding to amino acids 222-234 of mouse DLL3. Percent identity by BLAST analysis: Mouse, Rat (100%); Hamster (92%); Galago, Rabbit, Pig, Bovine, Guinea pig (85%).
Rabbit anti-mouse Delta-like protein 3 recognizes mouse Delta-like protein 3 (DLL3), one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. DLL3 is predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis, where it plays a role in somite segmentation, during early development. DLL3 acts as a regulator of Notch 1, as an inhibitor of primary neurogenesis, and studies in mice have linked DLL3-Notch signalling with liver regeneration, and developmental defects. More than 25 mutations in the DLL3 gene are known to be responsible for the autosomal recessive skeletal malformation condition known as spondylocostal dysostosis type 1 (SCDO1), associated with vertebral and rib segmentation defects.


PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About Delta3 / DLL3

Q9NYJ7 NM_016941 NP_058637.1

DLL3 Antibody, Delta (Drosophila)-like 3 Antibody, Delta-like 3 (Drosophila) Antibody, Delta-like protein 3 Antibody, Delta3 Antibody, Drosophila Delta homolog 3 Antibody, SCDO1 Antibody

Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.

Western blot

Western blot
Mouse brain lysate probed with Rabbit anti-Mouse Delta-Like Protein 3 followed by Sheep anti-Rabbit IgG:HRP

Requested From: United States
Date Requested: 10/28/2016

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