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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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DEC‑205 / CD205 / LY75 Antibody (clone MIDC‑8) LS‑C96361
Antibody
LY75 antibody LS-C96361 is an unconjugated rat monoclonal antibody to mouse LY75 (DEC-205 / CD205). Validated for IHC.
Catalog
Size
Price
LS-C96361-200
200 µg
Unavailable

Popular DEC-205 / CD205 / LY75 Products

Anti-LY75 / DEC-205 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2669 concentration 10 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin
Antibody
Species: Mouse
Applications: IHC, IHC - Frozen
Antibody
Species: Mouse
Applications: IHC, IHC - Frozen, Flow Cytometry
Formalin-fixed and paraffin-embedded human spleen tissue reacted with LY75 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, Flow Cytometry
Antibody
Species: Bovine, Sheep
Applications: IHC, IHC - Frozen, Immunoprecipitation, Flow Cytometry

Product Description

LY75 antibody LS-C96361 is an unconjugated rat monoclonal antibody to mouse LY75 (DEC-205 / CD205). Validated for IHC.
About DEC-205 / CD205 / LY75
LY75/CD205/DEC-205 is an integral membrane protein homologous to the macrophage mannose receptor and functions as an antigen-uptake receptor on dendritic cells. DEC-205 is rapidly taken up by means of coated pits and vesicles and is delivered to a multivesicular endosomal compartment that resembles the MHC class II-containing vesicles. O60449 NM_002349 NP_002340.2

LY75 Antibody, CD205 Antibody, CLEC13B Antibody, CD205 antigen Antibody, LY-75 Antibody, Lymphocyte antigen 75 Antibody, DEC-205 Antibody, gp200-MR6 Antibody


Specifications

Target
DEC-205 / CD205 / LY75
Host
Rat
Reactivity
Mouse (tested or 100% immunogen sequence identity)
Clonality
Monoclonal [MIDC-8]
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Frozen (1:80)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Lymph node
Specificity
The antigen is found in dendritic cells. The MIDC-8 antigen is localized in the cytoplasm as distinct spots near the nucleus. Immunohistological analyses indicate that the antigen recognized by MIDC-8 and NLDC-145 may be biochemically related. Antigen distribution: Isolated cells: The antigen is found in dendritic cells. MIDC-8 does not stain thymic epithelial cells which are the major contaminants in thymic dendritic cell preparations. The antigen is also absent in blood cells, bone marrow cells or macrophages isolated from the peritoneal cavity. Tissue sections: The antigen is found in interdigitating cells in T cell dependent areas of secondary lymphoid organs, the medulla of thymus, veiled cells, and very weakly in Langerhans cells. Specificity: Mouse: interdigitating cells, dendritic cells Other species: unknown
Presentation
Lyophilized from PBS pH 7.2, 10mg/ml BSA, 0.01% thimerosal
Reconstitution
0.5ml distilled water
Storage
Store at 4°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/24/2018

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