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DDX23 / PRP28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
DDX23 / PRP28 is a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.
| Gene Name: | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 |
| Family/Subfamily: | DEAD box protein |
| Synonyms: | DDX23, DEAD box protein 23, PRP28 homolog, yeast, PRPF28, Prp28, U5-100KD, U5 snRNP 100 kD protein, PRP28 homolog, PRP28p homolog, U5-100K |
| Target Sequences: | NM_004818 NP_004809.2 Q9BUQ8 |
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