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Anti-DDB2 Antibody (C-Terminus) LS-C18970

Ordering

Wt. Vol. Conc. Price
- 100 µl - $405
Inquire for larger quantities

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206-374-1102
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Most Popular DDB2 Antibodies

Anti-DDB2 Antibody (C-Terminus) LS-C128545
Rabbit Polyclonal to Human DDB2
Human
Western blot, ELISA
Unconjugated
Anti-DDB2 Antibody LS-C310101
Rabbit Polyclonal (IgG) to Human DDB2
Human
Western blot
Unconjugated
Anti-DDB2 Antibody LS-C331725
Rabbit Polyclonal (IgG) to Human DDB2
Human, Mouse, Rat
IHC, Immunofluorescence, Western blot
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (2)
Rabbit Polyclonal to Human DDB2
Human
Western blot, Immunoprecipitation, ELISA
Unconjugated

Details

Human DDB2
Rabbit
Human (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Delipidated and defibrinated
Unmodified

Applications

  • Western blot (1:500 - 1:1000)
  • Immunoprecipitation
  • ELISA (1:2000 - 1:10000)

Specificity and Use

DDB2 antibody was raised against synthetic peptide from human DDB2.
C-Terminus
Amino acids 419-427 of Human DDB2 (C-terminal) coupled to KLH.
This antibody reacts with human DDB2 by western blot and immunoprecipitation. The antibody immunoprecipitates in vitro translated protein and protein from cell lysates (using 293T, and others). Coimmunoprecipitation of related proteins has not been tested. A 47.8 kD band corresponding to human DDB2 is detected. Most cell lines expressing DDB2 can be used as a positive control. Researchers should determine optimal titers for other applications.

Packaging

Serum. Supplied as a liquid, 0.1% sodium azide.
Store vial at -20 C prior to opening. Aliquot contents and freeze at -20 C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
For research use only.

Publications (2)

1
The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription. Shiyanov P, Hayes SA, Donepudi M, Nichols AF, Linn S, Slagle BL, Raychaudhuri P. Molecular and cellular biology. 1999 19:4935-43. [PubMed:10373543] [PMC:PMC84302]
2
Cullin 4A associates with the UV-damaged DNA-binding protein DDB. Shiyanov P, Nag A, Raychaudhuri P. The Journal of biological chemistry. 1999 274:35309-12. [PubMed:10585395]

About DDB2

Q92466 NM_000107 NP_000098.1

DDB2 Antibody, DNA damage-binding protein 2 Antibody, DDB p48 subunit Antibody, UV-DDB 2 Antibody, DDBB Antibody, UV-DDB2 Antibody

Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches.

Requested From: United States
Date Requested: 12/8/2016

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