Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
DDB1 Antibody, DDB p127 subunit Antibody, DDBA Antibody, HBV X-associated protein 1 Antibody, UV-DDB1 Antibody, XAP-1 Antibody, XPE Antibody, XPE-binding factor Antibody, UV-damaged DNA-binding factor Antibody, XPCE Antibody, DNA damage-binding protein 1 Antibody, DNA damage-binding protein a Antibody, UV-DDB 1 Antibody, XAP1 Antibody, XPE-BF Antibody
Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches.
IHC of paraffin-embedded Cal27 Xenograft using DDB1 antibody at 1:500 dilution.
Immunofluorescence of paraformaldehyde-fixed HeLa using DDB1 antibody at 1:200 dilution.
Sample (50 ug of whole cell lysate). A: Mouse brain. 5% SDS PAGE. DDB1 antibody diluted at 1:5000.
Sample (30 ug of whole cell lysate). A: NIH-3T3. 7.5% SDS PAGE. DDB1 antibody diluted at 1:1000.
Sample (30 ug of whole cell lysate). A: Hep G2 . 7.5% SDS PAGE. DDB1 antibody diluted at 1:1000.
DDB1 antibody immunoprecipitates DDB1 protein in IP experiments. IP Sample:1000 ug HeLa whole cell lysate/extract A. 40 ug HeLa whole cell lysate/extract B. Control with 2.5 ug of preimmune rabbit IgG C. Immunoprecipitation of DDB1 protein by 2.5 ug of DDB1 antibody 7.5% SDS-PAGE The immunoprecipitated DDB1 protein was detected by DDB1 antibody diluted at 1:1000. EasyBlot anti-rabbit IgG (anti-rabbit IgG (HRP) -01) was used as a secondary reagent.