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DAZ3
deleted in azoospermia 3
DAZ3 is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat.
| Gene Name: | deleted in azoospermia 3 |
| Family/Subfamily: | DAZ |
| Synonyms: | DAZ3, Deleted in azoospermia 3, PDP1679 |
| Target Sequences: | NM_020364 NP_065097.2 Q9NR90 |
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