Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation
Mouse Monoclonal (IgG1) to Human DAXX
IHC - Frozen, Western blot
Human (tested or 100% immunogen sequence identity)
Protein A purified
IHC - Frozen
Specificity and Use
DAXX antibody was raised against recombinant C-terminal DAXX protein (aa 558-740).
Recognizes the apoptosis related protein DAXX. DAXX is a regulator of apoptosis implicated in Fas and TGF beta induced apoptosis. DAXX is predominantly a nuclear protein, where it as a repressor of EtsI and Pax3 transactivation. When in association with ASK1 kinase DAXX translocates from the nucleus to the cytoplasm.
DAXX Antibody, BING2 Antibody, CENP-C binding protein Antibody, DAP6 Antibody, Death-associated protein 6 Antibody, EAP1 Antibody, Fas-binding protein Antibody, HDaxx Antibody, ETS1-associated protein 1 Antibody
Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby.