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DAP12

TYRO protein tyrosine kinase binding protein

DAP12 is a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.

Gene Name: TYRO protein tyrosine kinase binding protein
Synonyms: TYROBP, DNAX-activation protein 12, DAP12, PLOSL, KARAP, KAR-associated protein, PLO-SL
Target Sequences: NM_003332 NP_003323.1 O43914

Publications (1)

1
A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. Varnum MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, Koro L, Ikezu S, Ikezu T. The Journal of biological chemistry. 2017 June;292:10651-10663. [Full Text Article] [PubMed:28490631] [PMC:PMC5481570]

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Antibodies (15)
Proteins (7)
ELISA Kits (6)
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DAP12 (28)
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rabbit (14)
goat (1)
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polyclonal pc (15)
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aa85-113 (7)
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Purified (1)
DAP12 Antibody - Anti-DAP12 antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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DAP12 Rabbit anti-Human Polyclonal (aa85-113) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
DAP12 Antibody - Anti-TYROBP / DAP12 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.
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DAP12 Goat anti-Human Polyclonal Antibody
Dog, Horse, Bat, Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$460
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DAP12 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$503
DAP12 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
DAP12 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
DAP12 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
DAP12 Antibody - Immunoprecipitation using DAP12 antibody on MHC class I (1) and NKp44 (2) positive cells.
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DAP12 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
100 µg/$466
DAP12 Antibody - Western blot analysis of extracts of mouse pancreas, using TYROBP antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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DAP12 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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DAP12 Rabbit anti-Human Polyclonal (aa85-113) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
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DAP12 Rabbit anti-Human Polyclonal (aa85-113) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
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DAP12 Rabbit anti-Human Polyclonal (aa85-113) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
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DAP12 Rabbit anti-Human Polyclonal (aa85-113) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
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DAP12 Rabbit anti-Human Polyclonal (aa85-113) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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DAP12 Rabbit anti-Human Polyclonal (aa85-113) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
DAP12 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
9.3 kDa
20 µg/$150
DAP12 Antibody - 1:100 staining human Head and neck carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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DAP12 Rabbit anti-Human Polyclonal Antibody
Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
DAP12 Antibody - Immunohistochemistry of paraffin-embedded Rat heart using TYROBP Polyclonal Antibody at dilution of 1:100 (40x lens).
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DAP12 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
DAP12 Antibody - Immunochemical staining of human TYROBP in human lung with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.
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DAP12 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
100 µl/$412
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DAP12 Rabbit anti-Rat Polyclonal Antibody
Rat
WB
Unconjugated
200 µg/$528
DAP12 Protein - Purified recombinant protein TYROBP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
9.3 kDa
20 µg/$1,107
DAP12 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
DAP12 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
12.18 kDa
20 µg/$150
DAP12 ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
DAP12 ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
DAP12 ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$783
Viewing 1-25 of 28 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).