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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cytokeratin 8+18 Antibody LS‑C64375
Cytokeratin 8+18 antibody LS-C64375 is an unconjugated mouse monoclonal antibody to human Cytokeratin 8+18. Validated for IHC.
Antibody
Catalog
Size
Price
LS-C64375-1000
1000 µl
Unavailable

Popular Cytokeratin 8+18 Products

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Species: Bovine, Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, IHC - Frozen, Western blot, ELISA
Anti-Keratin 8/18 antibody IHC of human prostate, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8548 dilution 10 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin
Anti-Keratin 8/18 antibody IHC of human prostate, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8631 dilution 1:50.
Species: Human
Applications: IHC, IHC - Paraffin
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: IHC, IHC - Paraffin, ICC, Flow Cytometry
Formalin-fixed, paraffin-embedded human lung carcinoma stained with Cytokeratin 8 + 18 antibody (B22.1 + B23.1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry

Product Description

Cytokeratin 8+18 antibody LS-C64375 is an unconjugated mouse monoclonal antibody to human Cytokeratin 8+18. Validated for IHC.
About Cytokeratin 8+18
Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

Specifications

Target
Human Cytokeratin 8+18
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • IHC - Frozen
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Human keratin 8 alpha 18. Expected Staining Pattern: Cytoplasmic and membrane.
Specificity
Recognizes human cytokeratins with molecular weights 52 and 45kD, corresponding to cytokeratins 8 and 18, respectively. Useful in the detection of adenocarcinomas, mesotheliomas and certain squamous epithelia-derived carcinomas. Interestingly, some epithelial tumors demonstrate cytokeratin 8 and 18 expression, but normal strati ed squamous epithelium does not.
Usage
Suitable for use in Immunohistochemistry. Immunohistochemistry: Stains cytokeratins 8 and 18 in frozen tissue or formalin-fixed, paraffin-embedded (FFPE) tissue sections.
Presentation
PBS, pH 7.4, 1% BSA, 0.1% sodium azide.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 7/19/2018

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