Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
CYR61 antibody was raised against a synthetic peptide made to the C-terminal region of the human CYR61 protein sequence Percent identity by BLAST analysis: Xenopus (99%); Chicken (93%); Rat, Mouse (80%).
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
CYR61 Antibody, GIG1 Antibody, IGFBP10 Antibody, Protein CYR61 Antibody, CCN family member 1 Antibody, CCN1 Antibody, IBP-10 Antibody, IGF-binding protein 10 Antibody, IGFBP-10 Antibody, Protein GIG1 Antibody
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1.