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Anti-CYP46A1 / CYP46 Antibody (C-Terminus) LS-C56817


Wt. Vol. Conc. Price
- 100 µl - $355
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular CYP46A1 / CYP46 Antibodies

Anti-CYP46A1 / CYP46 Antibody IHC-plus™ LS-B279
Rabbit Polyclonal to Human CYP46A1 / CYP46
IHC - Paraffin, ICC, Western blot
Immunohistochemistry Image
Anti-CYP46A1 / CYP46 Antibody (aa396-445) LS-C80601
Rabbit Polyclonal (IgG) to Human CYP46A1 / CYP46
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Xenopus
Western blot
Western blot Image
Anti-CYP46A1 / CYP46 Antibody LS-C155427
Rabbit Polyclonal (IgG) to Human CYP46A1 / CYP46
Western blot
Western blot Image

100% Guaranteed 100% Guaranteed
Goat Polyclonal to Human CYP46A1 / CYP46
Western blot, ELISA


Human CYP46A1 / CYP46
Human (tested or 100% immunogen sequence identity)


  • Western blot (1:3000)
  • ELISA (1:15000)

Specificity and Use

CYP46A1 / CYP46 antibody was raised against synthetic peptide corresponding to amino acid sequence 254-270 of human cholesterol 24-hydroxylase protein.
Recognizes cholesterol 24-hydroxylase (CYP46A1), a 58 kD member of the Cytochrome P450 family, expressed in the brain. CYP46A1 converts cholesterol into the biologically active oxysterol and 24(S)-hydroxycholesterol, in the first step of the enzymatic degradation of cholesterol in the brain. CYP46A1 is also thought to play a role in the metabolism of neurosteroids and drugs that can cross the blood-brain barrier and are targeted to the central nervous system. P450 enzymes are divided into two groups: steroidogenic and xenobiotic. The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism. Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members: CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1.
Western Blot: LS-C56817 detects a band of approximately 58kD in human Alzheimer diseased brain lysates.


Serum, 0.09% sodium azide.
Long term: -20°C; Short term: -20°C
For research use only.

About CYP46A1 / CYP46

Q9Y6A2 NM_006668 NP_006659.1

CYP46A1 Antibody, Cytochrome P450 46A1 Antibody, Cholesterol 24-hydroxylase Antibody, CH24H Antibody, CP46 Antibody, CYP46 Antibody

CYP46A1 / CYP46 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol.

Requested From: United States
Date Requested: 10/26/2016

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