CYP2D6

cytochrome P450, family 2, subfamily D, polypeptide 6

CYP2D6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Antibodies (63)

Proteins (10)

ELISA Kits (5)

Type

Cell-Based (1)

Over-Expression Lysate (6)

Primary (63)

Recombinant (4)

Sandwich (4)

Target

CYP2D6 (78)

Reactivity

Human (67)

Mouse (15)

Rat (19)

Chimpanzee (6)

Gibbon (3)

Hamster (3)

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Peptide-ELISA (7)

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rabbit (59)

mouse (3)

goat (1)

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IHCPlus (2)

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IgG (39)

IgG2a (1)

IgG2a,k (1)

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monoclonal mc (2)

polyclonal pc (61)

Clone

2C5 (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (4)

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APC Conjugated (3)

Azide-free (1)

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aa236-472 (8)

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Ala277 (1)

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aa1-497 (1)

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No (78)

Sample Type

Adherent Cell Cultures (1)

Cell Lysates (1)

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DDK,C-terminus (1)

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His (1)

Myc-DDK (Flag) (7)

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Source

293T Cells (3)

E. coli (1)

HEK 293 Cells (5)

Wheat Germ Extract (1)

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IHC-plus™ CYP2D6 Antibody (C-Terminus) LS-B13571

(4.0) Rating

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ CYP2D6 Antibody (Internal) LS-B13570

(4.0) Rating

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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CYP2D6 Antibody (Internal) LS-C368579

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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CYP2D6 Antibody (aa150-497) LS-C752432

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (aa150-497) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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CYP2D6 Antibody (aa101-150) LS-C40339

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (aa101-150) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$397

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CYP2D6 Antibody LS-C109528

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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CYP2D6 Antibody (aa76-105) LS-C167225

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (aa76-105) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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CYP2D6 Antibody (N-Terminus) LS-C352094

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$299

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CYP2D6 Antibody (Internal) LS-C352096

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human, Monkey

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$299

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CYP2D6 Antibody (C-Terminus) LS-C107627

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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Human CYP2D6 (Sandwich ELISA) ELISA Kit - LS-F14051

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human CYP2D6 (Cell-Based ELISA) ELISA Kit - LS-F3294

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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CYP2D6 Antibody LS-C661985

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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CYP2D6 Antibody LS-C752433

Antibody:

CYP2D6 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

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CYP2D6 Antibody LS-C742798

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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CYP2D6 Antibody (aa76-105) LS-C320719

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (aa76-105) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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CYP2D6 Antibody (aa76-105, Biotin) LS-C208767

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (aa76-105) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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CYP2D6 Antibody (aa76-105, FITC) LS-C208768

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (aa76-105) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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CYP2D6 Antibody (aa76-105, APC) LS-C208766

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (aa76-105) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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CYP2D6 Antibody (aa76-105, PE) LS-C208771

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (aa76-105) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

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CYP2D6 Antibody (aa76-105, Azide-free, HRP) LS-C208769

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (aa76-105) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

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CYP2D6 Antibody LS-C824887

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

CYP2D6 Antibody (220-300 aa, Internal) LS-C383006

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (220-300 aa, Internal) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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CYP2D6 Antibody (aa224-273) LS-C291859

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal (aa224-273) Antibody

Reactivity:

Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

CYP2D6 Antibody LS-C781956

Antibody:

CYP2D6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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