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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CYP2C19 Antibody (aa257‑285) LS‑C167222
CYP2C19 antibody LS-C167222 is an unconjugated rabbit polyclonal antibody to human CYP2C19. Validated for IHC and WB.
Catalog
Size
Price
LS-C167222-400
400 µl
Unavailable

Popular CYP2C19 Products

CYP2C19 antibody LS-C110653 Western blot of Placenta lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Bovine, Sheep
Applications: Western blot
Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with CYP2C19 Antibody ,which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot
IHC of CYP2C19 (K270) pAb in paraffin-embedded human liver carcinoma tissue.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot
Immunohistochemical analysis of Cytochrome P450 2C19 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Species: Human, Monkey
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Western blot of CYP2C19 antibody
Species: Human
Applications: IHC, Immunofluorescence, Western blot, ELISA

Product Description

CYP2C19 antibody LS-C167222 is an unconjugated rabbit polyclonal antibody to human CYP2C19. Validated for IHC and WB.
About CYP2C19
CYP2C19 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. P33261 NM_000769 NP_000760.1

CYP2C19 Antibody, CYPIIC17 Antibody, CYPIIC19 Antibody, CPCJ Antibody, Cytochrome P450 2C19 Antibody, Cytochrome P450-11A Antibody, Cytochrome P450-254C Antibody, Mephenytoin 4-hydroxylase Antibody, p450C2C Antibody, p450IIC19 Antibody, S-mephenytoin 4-hydroxylase Antibody, CYP2C Antibody, Cytochrome P-450 II C Antibody


Specifications

Target
Human CYP2C19
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Ammonium sulfate precipitation
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:10 - 1:50)
  • Western blot (1:1000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Blocking Peptide
LS-E8404 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C167222. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa257-285
Specificity
This CYP2C19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-285 amino acids from the Central region of human CYP2C19.
Presentation
PBS, 0.09% sodium azide
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

CYP2C19 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
CYP2C19 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Western blot

Western blot of CYP2C19 Antibody in Jurkat cell line lysates (35 ug/lane). CYP2C19 (arrow) was detected using the purified antibody.
Western blot of CYP2C19 Antibody in Jurkat cell line lysates (35 ug/lane). CYP2C19 (arrow) was detected using the purified antibody.

Immunohistochemistry

CYP2C19 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
CYP2C19 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Western blot

Western blot of CYP2C19 Antibody in Jurkat cell line lysates (35 ug/lane). CYP2C19 (arrow) was detected using the purified antibody.
Western blot of CYP2C19 Antibody in Jurkat cell line lysates (35 ug/lane). CYP2C19 (arrow) was detected using the purified antibody.

Immunohistochemistry

CYP2C19 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
CYP2C19 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Western blot

Western blot of CYP2C19 Antibody in Jurkat cell line lysates (35 ug/lane). CYP2C19 (arrow) was detected using the purified antibody.
Western blot of CYP2C19 Antibody in Jurkat cell line lysates (35 ug/lane). CYP2C19 (arrow) was detected using the purified antibody.

Immunohistochemistry

CYP2C19 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
CYP2C19 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Western blot

Western blot of CYP2C19 Antibody in Jurkat cell line lysates (35 ug/lane). CYP2C19 (arrow) was detected using the purified antibody.
Western blot of CYP2C19 Antibody in Jurkat cell line lysates (35 ug/lane). CYP2C19 (arrow) was detected using the purified antibody.


Requested From: 
Date Requested: 6/24/2018

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