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Anti-CYP1A2 Antibody LS-C6335

Ordering

Wt. Vol. Conc. Price
- 50 µl - $665
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CYP1A2 Antibodies

Anti-CYP1A2 Antibody LS-C14776
Rabbit Polyclonal (IgG) to Human CYP1A2
Human, Rat
IHC - Frozen, Western blot
Unconjugated
Anti-CYP1A2 Antibody (clone 2C6) LS-C172346
Mouse Monoclonal [clone 2C6] (IgG1) to Human CYP1A2
Human
IHC - Paraffin, Western blot, Flow Cytometry
Unconjugated
Immunohistochemistry Image

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Rabbit Polyclonal (IgG) to Human CYP1A2
Human
Western blot, Functional Assay
Unconjugated

Details

Human CYP1A2
Rabbit
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Antiserum
Unmodified

Applications

  • Western blot (1:5000 - 1:10000)
  • Functional Assay

Specificity and Use

CYP1A2 antibody was raised against purified human CYP1A2 expressed in E. coli.
Recognizes human cytochrome p450 1A2 (CYP1A2). P450 enzymes are divided into two groups: steroidogenic and xenobiotic. The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism. Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members: CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1. The product is a neutralizing antibody which is a specific and potent inhibitor of CYP1A2 activity. S.
Suitable for use in Western Blot and Functional Assays. Western Blot: 1:5000-1:10000. Inhibition Assays: 1-20ul.

Packaging

Serum - liquid.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About CYP1A2

P05177 NM_000761 NP_000752.2

CYP1A2 Antibody, Aryl hydrocarbon hydroxylase Antibody, Cytochrome P(3)450 Antibody, Cytochrome P450 1A2 Antibody, Cytochrome P450 4 Antibody, p450 form 4 Antibody, p3-450 Antibody, p450(PA) Antibody, CP12 Antibody, CYPIA2 Antibody, Cytochrome p450 ia2 Antibody, Cytochrome P450-P3 Antibody, Dioxin-inducible P3-450 Antibody

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen.

Requested From: United States
Date Requested: 12/7/2016

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