Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Atlantic cod (tested or 100% immunogen sequence identity)
Specificity and Use
CYP1A1 antibody was raised against cytochrome P450 1A from Atlantic cod.
Recognizes a petroleum/PAH/PCB/dioxin-inducible protein (mr 55000-59000) in liver samples from a wide variety of different fish species including cod (Gadiformes), carp (Cypriniformes), salmon (Salmoniformes) and some flatfish (Pleuronectiformes).
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Western Blot (Cod): 1:500-1:1000. Western Blot (Other species):1:50-1:100.
PBS, 0.1% sodium azide, 1% BSA.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke.