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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CYLD Antibody (aa32‑45) LS‑C19400
CYLD antibody LS-C19400 is an unconjugated rabbit polyclonal antibody to CYLD from human, mouse, bovine and other species. Validated for ICC and WB.
Catalog
Size
Price
LS-C19400-100
100 µg (1 mg/ml)
Unavailable

Popular CYLD Products

Antibody
Species: Human, Monkey, Mouse, Bovine, Dog, Hamster, Horse, Rabbit
Applications: ELISA
Anti-CYLD antibody IHC of mouse brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4323 concentration 5 ug/ml.
Species: Mouse, Rat, Hamster
Applications: IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
WB using CYLD Antibody (733)
Species: Human, Mouse, Rat, Bovine, Horse, Primate
Applications: ICC, Immunofluorescence, Western blot
CYLD antibody Western blot. All lanes: Anti CYLD at 0.5 ug/ml. Lane 1: Rat Testis Tissue Lysate at 50 ug. Lane 2: Rat Brain Tissue Lysate at 50 ug. Lane 3: HELA Whole Cell Lysate at 40 ug. Predicted band size: 107 kD. Observed band size: 107 kD.
Species: Human, Rat, Bovine, Horse, Pig, Sheep
Applications: Western blot

Product Description

CYLD antibody LS-C19400 is an unconjugated rabbit polyclonal antibody to CYLD from human, mouse, bovine and other species. Validated for ICC and WB.
About CYLD
Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Q9NQC7 NM_015247 CAB93533.1

CYLD Antibody, CDMT Antibody, Deubiquitinating enzyme CYLD Antibody, CYLDI Antibody, EAC Antibody, HSPC057 Antibody, MFT1 Antibody, MFT Antibody, SBS Antibody, TEM Antibody, BRSS Antibody, Ubiquitin thiolesterase CYLD Antibody, USPL2 Antibody, CYLD1 Antibody, KIAA0849 Antibody, Ubiquitin thioesterase CYLD Antibody


Specifications

Target
Human CYLD
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Bovine, Dog, Guinea pig, Hamster, Horse, Rabbit, Chicken (tested or 100% immunogen sequence identity)
Predicted
Rat (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • ICC (5 µg/ml)
  • Western blot (2 - 4 µg/ml)
Immunogen
CYLD antibody was raised against a synthetic peptide (DKQTQKLLKVPKGS) corresponding to amino acids 32-45 of human CYLD, GenBank no. ref|NP_001035814.1|. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Dog, Bovine, Hamster, Panda, Horse, Rabbit, Guinea pig, Turkey, Zebra finch, Chicken (100%); Rat, Elephant, Platypus (93%); Opossum (86%).
Epitope
aa32-45
Specificity
The amino acid sequence used has 100% identity in human, mouse, chimpanzee, bovine and feline, and 92% homologous in rat. Human CYLD is a 956 amino acid protein and the approximate theoretical size is 105 kD.
Presentation
PBS, 0.05% sodium azide.
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunocytochemistry

ICC staining of HeLa cell using control (rabbit Ig) at 5 ug/ml.
ICC staining of HeLa cell using control (rabbit Ig) at 5 ug/ml.

Immunocytochemistry

ICC staining of HeLa cell using antibody (CYLD) at 5 ug/ml.
ICC staining of HeLa cell using antibody (CYLD) at 5 ug/ml.

Western blot

Western blot of CYLD in HeLa cell lysate using antibody at 2 ug/ml.
Western blot of CYLD in HeLa cell lysate using antibody at 2 ug/ml.

Immunocytochemistry

ICC staining of HeLa cell using control (rabbit Ig) at 5 ug/ml.
ICC staining of HeLa cell using control (rabbit Ig) at 5 ug/ml.

Immunocytochemistry

ICC staining of HeLa cell using antibody (CYLD) at 5 ug/ml.
ICC staining of HeLa cell using antibody (CYLD) at 5 ug/ml.

Western blot

Western blot of CYLD in HeLa cell lysate using antibody at 2 ug/ml.
Western blot of CYLD in HeLa cell lysate using antibody at 2 ug/ml.

Immunocytochemistry

ICC staining of HeLa cell using control (rabbit Ig) at 5 ug/ml.
ICC staining of HeLa cell using control (rabbit Ig) at 5 ug/ml.

Immunocytochemistry

ICC staining of HeLa cell using antibody (CYLD) at 5 ug/ml.
ICC staining of HeLa cell using antibody (CYLD) at 5 ug/ml.

Western blot

Western blot of CYLD in HeLa cell lysate using antibody at 2 ug/ml.
Western blot of CYLD in HeLa cell lysate using antibody at 2 ug/ml.

Immunocytochemistry

ICC staining of HeLa cell using control (rabbit Ig) at 5 ug/ml.
ICC staining of HeLa cell using control (rabbit Ig) at 5 ug/ml.

Immunocytochemistry

ICC staining of HeLa cell using antibody (CYLD) at 5 ug/ml.
ICC staining of HeLa cell using antibody (CYLD) at 5 ug/ml.

Western blot

Western blot of CYLD in HeLa cell lysate using antibody at 2 ug/ml.
Western blot of CYLD in HeLa cell lysate using antibody at 2 ug/ml.


Requested From: 
Date Requested: 6/21/2018

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