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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CYBB / NOX2 / gp91phox Antibody (aa548‑560) LS‑C23974
Antibody
Gp91phox antibody LS-C23974 is an unconjugated rabbit polyclonal antibody to gp91phox (CYBB / NOX2) from human, mouse, rat and other species. Validated for WB.
Catalog
Size
Price
LS-C23974-200
200 µg (1 mg/ml)
Unavailable

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Product Description

Gp91phox antibody LS-C23974 is an unconjugated rabbit polyclonal antibody to gp91phox (CYBB / NOX2) from human, mouse, rat and other species. Validated for WB.
About CYBB / NOX2 / gp91phox
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. P04839 NM_000397 NP_000388.2

CYBB Antibody, Chronic granulomatous disease Antibody, CGD91-phox Antibody, Cytochrome b558 subunit beta Antibody, Cytochrome b(558) subunit beta Antibody, gp91-1 Antibody, gp91-PHOX Antibody, p22 phagocyte B-cytochrome Antibody, AMCBX2 Antibody, CGD Antibody, Cytochrome b-245 heavy chain Antibody, gp91PHOX Antibody, NADPH oxidase 2 Antibody, NOX2 Antibody, p91-PHOX Antibody


Specifications

Target
Human CYBB / NOX2 / gp91phox
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bat (tested or 100% immunogen sequence identity)
Predicted
Dog (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Protein A purified
Modifications
Unmodified
Applications
  • Western blot (1 - 4 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
Synthetic peptide corresponding to aa548-560 of human gp91-phox (KQSISNSESGPRG) (KLH-conjugated). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bat (100%); Elephant, Panda, Dog (92%); Dolphin, Bovine, Horse, Turkey, Chicken, Platypus (85%).
Epitope
aa548-560
Specificity
Recognizes human gp91 phox, Mr 75kD. Depending on the type of lysate, the amount loaded, the gel and the blot conditions, gp91 phox may run as a sharp band, Mr ~75kD, or appear as a smear between 75-91kD. Species sequence Homology: mouse-100%; bovine-11/13; porcine-10/13.
Usage
Suitable for use in Western Blot. (4 ug/ml). Proteins were visualized using a secondary antibody IgG (HRP) Pab Gt x Rb* and a chemiluminescence detection system. Positive control: Lung tissue, human neutrophil membrane, HL60 membrane and RIPA cell lysate.
Presentation
0.07 M Tris-glycine, pH 7.4, 0.105 M sodium chloride, 0.035% sodium azide, 30% glycerol.
Storage
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/24/2018

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