Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Western blot (applications tested for the base form of this product only)
Human CYBB / NOX2 / gp91phox
Human, Bat, Rabbit (tested or 100% immunogen sequence identity)
(applications tested for the base form of this product only)
Specificity and Use
CYBB / NOX2 / gp91phox antibody was raised against synthetic peptide located between aa512-561 of human CYBB (P04839, NP_000388). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Bat, Rabbit (100%).
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles.
NOX2 / gp91phox / gp91 phox antibody Western Blot of 721_B. Antibody dilution: 1 ug/ml. This image was taken for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested.
Requested From: United States
Date Requested: 10/24/2016