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Anti-CYBA / p22phox Antibody (clone CS9, FITC) LS-C185313

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Wt. Vol. Conc. Price
100 µg - 0.1 mg/ml $485

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Mouse Monoclonal [clone CS9] (IgG1) to Human CYBA / p22phox
Human
FITC Conjugated

Details

Human CYBA / p22phox
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [CS9]
Fluorescein (FITC)
Protein G purified

Specificity and Use

CYBA / p22phox antibody was raised against cytochrome B245 solubilised in octyl-beta-gluycopyranoside
The light chain of human Cytochrome B245. Epitope: aa165-169 (KKPSE), a cytosolic epitope on p22phox not accessible on intact neutrophils. Has an inhibitory effect on NADPH oxidase activation.

Packaging

PBS, 0.09% sodium azide, 1% BSA
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. Sensitive to light.
For research use only.

About CYBA / p22phox

P13498 NM_000101 NP_000092.2

CYBA Antibody, Cytochrome b(558) alpha chain Antibody, Cytochrome b-245 light chain Antibody, Cytochrome b558 subunit alpha Antibody, p22 phagocyte B-cytochrome Antibody, p22-PHOX Antibody, Cytochrome b light chain Antibody, p22phox Antibody

Cytochrome b is composed of cytochrome b alpha (CYBA; flavocytochrome b-558) and beta (CYBB; flavocytochrome b-245) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBA deficiency is associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles.

Requested From: United States
Date Requested: 5/23/2015

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