Human CXCR4

Goat

Human (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Affinity purified

Unmodified

Synthetic peptide TEEMGSGDYDSMKEPCFREENANFNKC corresponding to amino acids 17-43 within the N-Terminus of human CD184. Percent identity by BLAST analysis: Human, Chimpanzee (100%); Gorilla, Orangutan, Gibbon, Monkey (96%); Baboon, Tamarin, Dog (88%); Galago, Marmoset, Sheep, Elephant, Panda, Bovine, Cat, Rabbit (85%); Horse, Pig (81%).

aa17-43

Recognizes an epitope within the N-terminal (NT) region of human CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1). Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B- lymphopoiesis and myelopoiesis. CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates. Thisis reported as being suitable for use in immunofluorescence studies.

• IHC
• IHC - Paraffin (1:150)
• Western blot (1:250)
• ELISA (1:25000)

PBS, 0.1% Sodium Azide, 0.1% BSA

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P61073 NCBI: NM_003467 NP_003458.1