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Anti-CXCR4 Antibody (aa17-43) LS-C187839

Note: This antibody replaces LS-C121158

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $370
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CXCR4 Antibodies

Anti-CXCR4 Antibody (N-Terminus) IHC-plus™ LS-A1376
Rabbit Polyclonal to Human CXCR4
Human
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-CXCR4 Antibody (Cytoplasmic Domain) IHC-plus™ LS-A1380
Rabbit Polyclonal to Human CXCR4
Human, Monkey, Mouse, Rat, Hamster, Rabbit, Chicken
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-CXCR4 Antibody (clone 12G5) IHC-plus™ LS-B1986
Mouse Monoclonal [clone 12G5] (IgG2a) to Human CXCR4
Human, Baboon, Monkey
IHC - Paraffin, IHC - Frozen, Immunofluorescence, Flow Cytometry
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Goat Polyclonal (IgG) to Human CXCR4
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated

Details

Human CXCR4
Goat
Human (tested or 100% immunogen sequence identity)
Monkey (at least 90% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Affinity purified
Unmodified

Applications

  • IHC - Paraffin (1:150)
  • Western blot (1:250)
  • ELISA (1:25000)

Specificity and Use

CXCR4 antibody was raised against synthetic peptide TEEMGSGDYDSMKEPCFREENANFNKC corresponding to amino acids 17-43 within the N-terminal region of human CD184. Percent identity by BLAST analysis: Human, Chimpanzee (100%); Gorilla, Orangutan, Gibbon, Monkey (96%); Baboon, Tamarin, Dog (88%); Galago, Marmoset, Sheep, Elephant, Panda, Bovine, Cat, Rabbit (85%); Horse, Pig (81%).
aa17-43
Recognizes an epitope within the N-terminal (NT) region of human CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1). Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B- lymphopoiesis and myelopoiesis. CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates. Thisis reported as being suitable for use in immunofluorescence studies.

Packaging

PBS, 1% BSA, 0.1% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About CXCR4

P61073 NM_003467 NP_003458.1

CXCR4 Antibody, CD184 Antibody, CD184 antigen Antibody, Cmkar4 Antibody, Cxc chemokine receptor 4 Antibody, CXCR-4 Antibody, CXC-R4 Antibody, D2S201E Antibody, FB22 Antibody, Fusin Antibody, HM89 Antibody, LCR1 Antibody, NPY3R Antibody, NPYRL Antibody, NPYY3R Antibody, Npyy3 Antibody, HSY3RR Antibody, SDF-1 receptor Antibody, WHIM Antibody, C-x-c chemokine receptor 4 Antibody, LESTR Antibody, Neuropeptide Y receptor Y3 Antibody, NPYR Antibody

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation.

Immunohistochemistry

Immunohistochemistry
Immunohistochemistry of paraffin-embeddedi human spleen stained with Goat anti-Human CD184 (N-terminal)
 

Requested From: United States
Date Requested: 12/9/2016

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