Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
IHC - Paraffin (7 - 11 µg/ml)
Specificity and Use
CXCR1 antibody was raised against synthetic 20 amino acid peptide from N-terminal extracellular domain of human CXCR1. Percent identity with other species by BLAST analysis: Human (100%); Gorilla (95%); Chimpanzee (90%); Monkey (80%).
ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit. Wilson BJ, Saab KR, Ma J, Schatton T, P[Character fc]tz P, Zhan Q, Murphy GF, Gasser M, Waaga-Gasser AM, Frank NY, Frank MH. Cancer research. Aug;74:4196-207. [Full Text Article]
CXCR1 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord.