Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
CXCR1 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord.
Isolated human neutrophils were incubated with 0.25 g anti-human CXCR1 followed by staining with goat F(ab')2 anti-mouse IgG FITC [shaded peak]. Specificity of signal was confirmed by staining the neutrophils with 0.25 g mouse IgG1 isotype control followed by the secondary antibody [unshaded peak]. The data indicate that 100% of the isolated neutrophil population stains positive for this IL-8 receptor (M2 region).