Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 8F1-1-4] (IgG2b,k) to Human CXCR1
Human (tested or 100% immunogen sequence identity)
IgG2b,k Monoclonal [8F1-1-4]
Specificity and Use
CXCR1 antibody was raised against human IL8RA
This 8F1-1-4 (8F1-1-4) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood. This can be used at 20 ul (0.5 ug)/test per test. A test is defined as the amount (ug)/test of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Aqueous buffer, 0.09% sodium azide, contains stabilizer if necessary
CXCR1 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord.
Staining of normal human peripheral blood cells with PE anti-human CD182 (5E8-C7-F10) (LS-C106046) and FITC anti-human CD181 (8F1-1-4). Cells in the large scatter population were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of normal human peripheral blood cells with PE anti-human CD182 (5E8-C7-F10) (LS-C106046) and FITC Mouse IgG2b isotype control. Cells in the large scatter population were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.