(tested or 100% immunogen sequence identity)
CXCL10 / IP-10 antibody was raised against recombinant human IP-10.
Recognizes human IP-10 (10-kD interferon-inducible protein), otherwise known as CXCL10, a 77 amino acid CXC chemokine which, like monokine induced by IFN-gamma (Mig) and IFN-inducible T-cell alpha-chemoattractant (I-TAC), signals through the CXCR3 receptor. IP-10 acts as a chemoattractant for Th1 lymphocytes and natural killer (NK) cells and is secreted by a variety of cells, including neutrophils, monocytes, keratinocytes and epithelial cells, in response to interferon gamma (IFNgamma) and lipopolysaccharide (LPS). IP-10 is thus associated with several clinical conditions linked with Th1 type immune responses and raised IFNgamma expression, such as psoriasis, sarcoidosis and viral meningitis. In addition, studies have demonstrated the ability of IP-10 to suppress the synergistic action of stimulatory cytokines on hematopoietic progenitor cell proliferation.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.