Cullin 4B / CUL4B

cullin 4B

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.

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Products

Antibodies (36)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (36)

Recombinant (2)

Target

Cullin 4B / CUL4B (40)

Reactivity

Human (36)

Mouse (17)

Rat (12)

Bat (2)

Bovine (1)

Chicken (2)

Dog (5)

Fish (4)

Guinea pig (1)

Hamster (2)

Horse (2)

Monkey (3)

Pig (2)

Rabbit (2)

Sheep (1)

Zebrafish (5)

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Application

IHC (13)

IHC-P (5)

WB (31)

ELISA (12)

ICC (1)

IF (6)

IP (4)

Peptide-ELISA (1)

Host

rabbit (29)

mouse (7)

Isotype

IgG (23)

IgG1 (4)

IgG2b (2)

Clonality

monoclonal mc (6)

polyclonal pc (30)

Clone

OTI1C4 (2)

OTI7F8 (2)

OTI7G10 (2)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (1)

Carrier-free (3)

FITC Conjugated (1)

HRP Conjugated (1)

Magnetic beads Conjugated (1)

PE Conjugated (1)

Sepharose Conjugated (1)

Unconjugated (29)

Epitope

aa250-278 (7)

aa1-300 (3)

Internal (2)

aa895-913 (2)

aa1-200 (1)

aa50-100 (1)

aa863-913 (1)

Publications

No (40)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Cullin 4B / CUL4B Antibody (clone OTI1C4) LS-C175298

Antibody:

Cullin 4B / CUL4B Mouse anti-Human Monoclonal (OTI1C4) Antibody

Reactivity:

Mouse, Dog, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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Cullin 4B / CUL4B Antibody (aa1-300, clone OTI1C4, Carrier-free) LS-C788798

Antibody:

Cullin 4B / CUL4B Mouse anti-Human Monoclonal (aa1-300) (Carrier-free) (OTI1C4) Antibody

Reactivity:

Mouse, Dog, Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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Cullin 4B / CUL4B Antibody LS-C664868

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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Cullin 4B / CUL4B Antibody LS-C346081

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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Cullin 4B / CUL4B Antibody LS-C664869

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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Cullin 4B / CUL4B Antibody LS-C765890

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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Cullin 4B / CUL4B Antibody LS-C121681

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Fish, Zebrafish, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$564

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Cullin 4B / CUL4B Antibody (aa1-200) LS-C377403

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal (aa1-200) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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Cullin 4B / CUL4B Antibody LS-C816189

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF

Format:

Unconjugated

Price:

100 µl/$412

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Cullin 4B / CUL4B Antibody LS-C172036

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Fish, Zebrafish, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$380

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Cullin 4B / CUL4B Antibody (aa895-913) LS-C388300

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal (aa895-913) Antibody

Reactivity:

Chicken, Zebrafish, Pig, Horse, Bat, Sheep, Rabbit, Mouse, Guinea pig, Rat, Hamster, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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Cullin 4B / CUL4B Antibody (aa895-913) LS-C123350

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal (aa895-913) Antibody

Reactivity:

Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µg/$723

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Cullin 4B / CUL4B Antibody LS-C341790

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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Cullin 4B / CUL4B Antibody (aa863-913) LS-C290513

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal (aa863-913) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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Cullin 4B / CUL4B Antibody LS-C406334

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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Cullin 4B / CUL4B Antibody (aa250-278) LS-C320687

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal (aa250-278) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

Cullin 4B / CUL4B Antibody (aa250-278, Biotin) LS-C208713

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal (aa250-278) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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Cullin 4B / CUL4B Antibody (aa250-278, FITC) LS-C208714

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal (aa250-278) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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Cullin 4B / CUL4B Antibody (aa250-278, APC) LS-C208712

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal (aa250-278) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

Cullin 4B / CUL4B Antibody (aa250-278, PE) LS-C208717

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal (aa250-278) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

Cullin 4B / CUL4B Antibody (aa250-278, Azide-free, HRP) LS-C208715

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal (aa250-278) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

Cullin 4B / CUL4B Antibody LS-C307129

Antibody:

Cullin 4B / CUL4B Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µg/$705

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Cullin 4B / CUL4B Antibody LS-C742936

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

Cullin 4B / CUL4B Antibody (Internal) LS-C386947

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

Cullin 4B / CUL4B Antibody LS-C804023

Antibody:

Cullin 4B / CUL4B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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