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Anti-Cullin 4A / CUL4A Antibody (N-Terminus) IHC-plus™ LS-B360

Note: This antibody replaces LS-C19048

Ordering

Wt. Vol. Conc. Price
- 50 µl 85 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
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Most Popular Cullin 4A / CUL4A Antibodies

Anti-Cullin 4A / CUL4A Antibody (N-Terminus) IHC-plus™ LS-B360
Rabbit Polyclonal to Human Cullin 4A / CUL4A
Human
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (2)
Rabbit Polyclonal to Human Cullin 4A / CUL4A
Human
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated

Details

Human Cullin 4A / CUL4A
Rabbit
Human (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Delipidated and defibrinated
Unmodified

Applications

  • IHC - Paraffin (1:500)
  • Western blot (1:500 - 1:1000)
  • Immunoprecipitation
  • ELISA (1:2000 - 1:10000)

Specificity and Use

Cullin 4A / CUL4A antibody was raised against synthetic peptide from human CUL4A / Cullin 4A.
N-Terminus
Amino acids 1-20 of Human Cul4A (N-terminus) coupled to KLH.
Immunohistochemistry: LS-B360 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B360 was determined to be 1:500.

Packaging

0.01% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

Publications (2)

1
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM. Cell. 1996 85:829-39. [PubMed:8681378]
2
Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. Higa LA, Mihaylov IS, Banks DP, Zheng J, Zhang H. Nature cell biology. 2003 5:1008-15. [PubMed:14578910]

About Cullin 4A / CUL4A

Q13619 NM_003589 NP_003580.1

CUL4A Antibody, CUL-4A Antibody, Cullin-4A Antibody, Cullin 4A Antibody

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1.

Immunohistochemistry

Immunohistochemistry
Anti-CUL4A / Cullin 4A antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B360 dilution 1:500.
 

Requested From: United States
Date Requested: 12/4/2016

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