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Anti-CUL5 / Cullin-5 Antibody (N-Terminus) IHC-plus™ LS-B361

Note: This antibody replaces LS-C19011

Ordering

Wt. Vol. Conc. Price
- 50 µl 85 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CUL5 / Cullin-5 Antibodies

Anti-CUL5 / Cullin-5 Antibody (N-Terminus) IHC-plus™ LS-B361
Rabbit Polyclonal to Human CUL5 / Cullin-5
Human
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated
Immunohistochemistry Image
Anti-CUL5 / Cullin-5 Antibody (aa113-583) IHC-plus™ LS-B10803
Rabbit Polyclonal (IgG) to Human CUL5 / Cullin-5
Human
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-CUL5 / Cullin-5 Antibody LS-C334016
Rabbit Polyclonal (IgG) to Human CUL5 / Cullin-5
Human, Mouse, Rat
IHC, Immunofluorescence, Western blot
Unconjugated
Immunofluorescence Image

100% Guaranteed 100% Guaranteed Publications Publications (2)
Rabbit Polyclonal to Human CUL5 / Cullin-5
Human
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated

Details

Human CUL5 / Cullin-5
Rabbit
Human (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Delipidated and defibrinated
Unmodified

Applications

  • IHC - Paraffin (1:500)
  • Western blot (1:500 - 1:1000)
  • Immunoprecipitation
  • ELISA (1:2000 - 1:10000)

Specificity and Use

CUL5 / Cullin-5 antibody was raised against synthetic peptide from human CUL5 / Cullin 5.
N-Terminus
Amino acids 4-18 of Human Cul5 (N-terminus) coupled to KLH.
Immunohistochemistry: LS-B361 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B361 was determined to be 1:500.

Packaging

0.01% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

Publications (2)

1
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM. Cell. 1996 85:829-39. [PubMed:8681378]
2
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Ohta T, Michel JJ, Schottelius AJ, Xiong Y. Molecular cell. 1999 3:535-41. [PubMed:10230407]

About CUL5 / Cullin-5

Q93034 NM_003478 NP_003469.2

CUL5 Antibody, Cullin 5 Antibody, CUL-5 Antibody, VACM-1 Antibody, VACM1 Antibody, Cullin-5 Antibody

Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component.

Immunohistochemistry

Immunohistochemistry
Anti-CUL5 / Cullin 5 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B361 dilution 1:500.
 

Requested From: United States
Date Requested: 12/3/2016

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