CUL1 / Cullin 1

cullin 1

Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.

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Products

Antibodies (60)

Proteins (6)

ELISA Kits (1)

Type

Cell-Based (1)

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Primary (60)

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Target

CUL1 / Cullin 1 (67)

Reactivity

Human (61)

Mouse (22)

Rat (13)

Bat (4)

Bovine (6)

Chicken (5)

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Peptide-ELISA (3)

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rabbit (54)

mouse (6)

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IgG1,k (6)

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monoclonal mc (7)

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EPR3102Y (1)

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96-Well Microplate (1)

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700-780 aa, C-terminal (1)

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aa34-52 (1)

aa457-770 (1)

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Publications

No (66)

Yes (1)

Sample Type

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GST (1)

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Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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IHC-plus™ CUL1 / Cullin 1 Antibody (C-Terminus) LS-B2448

(4.0) Rating

Antibody:

CUL1 / Cullin 1 Mouse anti-Human Monoclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$485

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CUL1 / Cullin 1 Antibody (HRP) LS-C545415

Antibody:

CUL1 / Cullin 1 Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

HRP Conjugated

Price:

100 µl/$1,027

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CUL1 / Cullin 1 Antibody (Biotin) LS-C525294

Antibody:

CUL1 / Cullin 1 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Biotin Conjugated

Price:

100 µl/$1,027

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CUL1 / Cullin 1 Antibody (PE) LS-C653495

Antibody:

CUL1 / Cullin 1 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

PE Conjugated

Price:

100 µl/$1,027

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CUL1 / Cullin 1 Antibody (APC) LS-C516222

Antibody:

CUL1 / Cullin 1 Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

APC Conjugated

Price:

100 µl/$1,027

• Unconjugated
• HRP
• Biotin
• PE
• APC

• Unconjugated
• HRP
• Biotin
• More...
  • PE
  • APC

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IHC-plus™ CUL1 / Cullin 1 Antibody (aa750-776) LS-B357

(5.0) Rating

(2) Publication(s)

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal (aa750-776) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$515

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IHC-plus™ CUL1 / Cullin 1 Antibody (Internal, clone EPR3102Y) LS-B9302

(4.0) Rating

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Monoclonal (Internal) (EPR3102Y) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Flo, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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Mouse/Human CUL1 / Cullin 1 (Cell-Based ELISA) ELISA Kit - LS-F1920

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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IHC-plus™ CUL1 / Cullin 1 Antibody (aa727-776) LS-B7597

(4.0) Rating

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal (aa727-776) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

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CUL1 / Cullin 1 Antibody (C-Terminus) LS-C353049

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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CUL1 / Cullin 1 Antibody LS-C825918

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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CUL1 / Cullin 1 Antibody LS-C800263

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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CUL1 / Cullin 1 Antibody LS-C415839

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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CUL1 / Cullin 1 Antibody LS-C806365

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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CUL1 / Cullin 1 Antibody (700-780 aa, C-terminal) LS-C382952

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal (700-780 aa, C-terminal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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CUL1 / Cullin 1 Antibody (Tyr761) LS-C175981

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal (Tyr761) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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CUL1 / Cullin 1 Antibody LS-C664863

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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CUL1 / Cullin 1 Antibody LS-C658824

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$391

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CUL1 / Cullin 1 Antibody LS-C331929

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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CUL1 / Cullin 1 Antibody (N-Terminus) LS-C137116

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$332

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CUL1 / Cullin 1 Antibody (aa500-776) LS-C377362

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal (aa500-776) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

CUL1 / Cullin 1 Antibody (aa34-52) LS-C312714

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal (aa34-52) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Pig, Horse, Rabbit, Mouse, Guinea pig, Sheep, Bovine, Bat, Rat, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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CUL1 / Cullin 1 Antibody LS-C765886

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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CUL1 / Cullin 1 Antibody (C-Terminus) LS-C6251

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$786

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CUL1 / Cullin 1 Antibody LS-C192940

Antibody:

CUL1 / Cullin 1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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