Human CTSB / Cathepsin B

Sheep

Human (tested or 100% immunogen sequence identity)

IgG Polyclonal

FITC

Protein G purified

Unmodified

Native, from placenta

Detects cathepsin B, a lysosomal cysteine protease which functions as both a endopeptidase and a carboxypeptidase. Together with cathepsins D and L, cathepsin B is one of the most abundant proteases in the lysosome, and participates in intracellular protein degradation. Cathepsin B is thought to play an increasingly important role in apoptosis and its release from the lysosome under cell stress leads to Bid cleavage, cytochrome C release and nuclear fragmentation. Cathepsin B is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete processing of APP is thought to be a causative factor in Alzheimer disease. Over-expression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors, and has in particular been implicated in tumor invasion and metastasis.

• ELISA (1:1000 - 1:10000)

The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Do not use frost-free freezers. Store undiluted. Avoid freeze-thaw cycles. Protect from light. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

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Uniprot: P07858 NCBI: NM_001908 NP_001899.1