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Anti-CTNNB1 / Beta Catenin Antibody (phospho-Ser45) LS-C21256

Ordering

Wt. Vol. Conc. Price
- 10 blot - $530
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CTNNB1 / Beta Catenin Antibodies

Anti-CTNNB1 / Beta Catenin Antibody (C-Terminus) LS-C31415
Rabbit Polyclonal (IgG) to Human CTNNB1 / Beta Catenin
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Sheep, Chicken, Xenopus, Zebrafish
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-CTNNB1 / Beta Catenin Antibody (clone 4D5) IHC-plus™ LS-B4123
Mouse Monoclonal [clone 4D5] (IgG1) to Human CTNNB1 / Beta Catenin
Human
IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry, ELISA
Unconjugated
Immunohistochemistry Image
Anti-CTNNB1 / Beta Catenin Antibody (phospho-Ser552) LS-C381829
Rabbit Polyclonal (IgG) to Human CTNNB1 / Beta Catenin
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
Western blot Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human CTNNB1 / Beta Catenin
Human
Western blot, ELISA
Unconjugated

Details

Human CTNNB1 / Beta Catenin
Rabbit
Human (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • Western blot (1:1000 - 1:2000)
  • ELISA

Specificity and Use

CTNNB1 / Beta Catenin antibody was raised against synthetic phosphopeptide derived from a region of human -catenin that contains serine 45. The sequence is conserved in mouse, rat and frog.
pSer45
Human -catenin. Mouse, rat and frog -catenin (100% homologous) have not been tested, but are expected to react.
The antibody has been used for Western blotting applications. b-catenin (92kD) is a multifunctional protein involved in cell-cell adhesion, intracellular. signaling and gene transcription. b-catenin plays a key role in the Wnt pathway which mediates numerous developmental processes. Deregulation of the Wnt pathway results in the accumulation of b-catenin in the nucleus. Stabilizing mutations of several serine/threonine residues (more frequently of serine 45) have been found in multiple tumors. Phosphorylation of b-catenin on serine 45 by casein kinase I (CKI) primes its subsequent phosphorylation of residues 33, 37 and 41 by glycogen synthase-3b (GSK-3b) and results in its degradation. Applications: Suitable for use in ELISA, Western Blot. Western Blot: 1:1000-1:2000.

Packaging

PBS (without Mg2+, Ca2+), 1 mg/ml BSA (IgG, protease free), pH 7.2, 0.1% sodium azide, 50% glycerol.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
For research use only.

About CTNNB1 / Beta Catenin

P35222 NM_001904 NP_001895.1

CTNNB1 Antibody, Beta-catenin Antibody, Catenin beta-1 Antibody, CTNNB Antibody, Beta Catenin Antibody

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome.

Requested From: United States
Date Requested: 12/6/2016

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