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CTNNB1 / Beta Catenin
catenin (cadherin-associated protein), beta 1, 88kDa
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.
| Gene Name: | catenin (cadherin-associated protein), beta 1, 88kDa |
| Family/Subfamily: | Catenin , not assigned-Catenin |
| Synonyms: | CTNNB1, Beta-catenin, Catenin beta-1, CTNNB, Beta Catenin |
| Target Sequences: | NM_001904 NP_001895.1 P35222 |
Publications (7)
1
Wnt pathway-related gene expression during malignant progression in ulcerative colitis. van Dekken H, Wink JC, Vissers KJ, Franken PF, Ruud Schouten W, J Hop WC, Kuipers EJ, Fodde R, Janneke van der Woude C. Acta histochemica. 2007 109:266-72. (IHC)
[PubMed:17445872]
2
Pro-metastatic intracellular signaling of the elaidic trans fatty acid. Fujii K, Luo Y, Fujiwara-Tani R, Kishi S, He S, Yang S, Sasaki T, Ohmori H, Kuniyasu H. International journal of oncology. 2017 50:85-92. (WB; Human)
[Full Text Article]
[PubMed:27959384]
3
Nitric Oxide Mediates Crosstalk between Interleukin 1ß and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression. Zhong L, Schivo S, Huang X, Leijten J, Karperien M, Post JN. International journal of molecular sciences. 2017 November;18:pii: E2491. (Human)
[Full Text Article]
[PubMed:29165387]
[PMC:PMC5713457]
Related Antibodies: LS-C203657.
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CTNNB1 / Beta Catenin Mouse anti-Human Monoclonal (4D5) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Cancer Pathology
Cancer
CTNNB1 / Beta Catenin Mouse anti-Human Monoclonal (EM-22) Antibody
Mouse, Hamster, Human
Flo, ICC, IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
CTNNB1 / Beta Catenin Mouse anti-Human Monoclonal (7C5A2) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
CTNNB1 / Beta Catenin Mouse anti-Human Monoclonal (7C5D2) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (aa43-62) Antibody
Mouse, Rat, Hamster, Human, Monkey
IHC, IHC-P, WB
Unconjugated
1 Each/$555
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$818
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$856
CTNNB1 / Beta Catenin Mouse anti-Human Monoclonal (OTI1E10) Antibody
Dog, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (aa646-673) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (pSer37) Antibody
Zebrafish, Pig, Rat, Rabbit, Mouse, Dog, Sheep, Bovine, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
![CTNNB1 / Beta Catenin Antibody - Immunofluorescence of monoclonal antibody to CTNNB1 on HeLa cell. [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/ctnnb1-beta-catenin-antibody-clone-1c9-ls-c196999/144463_4848592.jpg)
CTNNB1 / Beta Catenin Mouse anti-Human Monoclonal (1C9) Antibody
Human
ELISA, IF, RNAi, WB
Unconjugated
100 µg/$423
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (aa78-106) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
CTNNB1 / Beta Catenin Mouse anti-Human Monoclonal (aa758-771) Antibody
Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
Cancer Pathology
Cancer
CTNNB1 / Beta Catenin Rabbit anti-Human Recombinant Monoclonal (CTNNB1/2030R) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
100 µg/$525
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (490-570 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Zebrafish, Pig, Mouse, Bovine, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (aa29-49) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Mouse, Dog, Rat, Hamster, Human, Monkey
ICC, IP, WB
Unconjugated
200 µg/$804
CTNNB1 / Beta Catenin Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (590-670 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Cancer Pathology
Cancer
CTNNB1 / Beta Catenin Mouse anti-Human Recombinant Monoclonal (rCTNNB1/2173) Antibody
Human
IF, IHC-P, WB
Unconjugated
100 µg/$525
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (aa723-751) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (aa692-721) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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