Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Rabbit, Chicken, Xenopus
IHC, IHC - Paraffin, Western blot, ELISA
Human CTNNA1 / Catenin Alpha-1
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Rabbit, Chicken, Xenopus (tested or 100% immunogen sequence identity)
IHC - Paraffin (3.75 µg/ml)
Western blot (1 - 3 µg/ml)
Specificity and Use
Synthetic peptide C-KREKQDETQTKIK from an internal region of human CTNNA1 (NP_001894.2). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Opossum, Turkey, Chicken, Lizard, Xenopus (100%).
LS-E26092 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-B4457. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Polarization of membrane associated proteins in the choroid plexus epithelium from normal and slc4a10 knockout mice. Christensen IB, Gyldenholm T, Damkier HH, Praetorius J. Frontiers in physiology. 2013 4:344. (IHC; Mouse)[Full Text Article]
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions.