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Anti-CTLA4 / CD152 Antibody (RPE) LS-C43850

Note: This antibody replaces LS-C57463

Ordering

Wt. Vol. Conc. Price
- 100 tst - $540
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CTLA4 / CD152 Antibodies

Anti-CTLA4 / CD152 Antibody (clone A3.4H2.H12, FITC) LS-C62860
Mouse Monoclonal [clone A3.4H2.H12] (IgG2a,k) to Human CTLA4 / CD152
Human
Flow Cytometry
FITC Conjugated
Anti-CTLA4 / CD152 Antibody (aa50-78) LS-C165112
Rabbit Polyclonal to Human CTLA4 / CD152
Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-CTLA4 / CD152 Antibody (clone KT56) LS-C193495
Mouse Monoclonal [clone KT56] (IgG1) to Human CTLA4 / CD152
Human
Western blot, ELISA
Unconjugated

100% Guaranteed 100% Guaranteed
Mouse Monoclonal (IgG2a) to Human CTLA4 / CD152
Human
IHC - Frozen, Flow Cytometry (applications tested for the base form of this product only)
RPE Conjugated

Details

Human CTLA4 / CD152
Mouse
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal
R. Phycoerythrin. Also available Unconjugated.
Affinity purified
Unmodified

Applications

  • IHC - Frozen
  • Flow Cytometry (1:1)
  • (applications tested for the base form of this product only)

Specificity and Use

CTLA4 / CD152 antibody was raised against human CTLA-4/human IgG heavy chain fusion protein.
Recognizes human CD152, also known as CTLA-4 (cytotoxic T-lymphocyte-associated antigen 4), an inhibitory receptor and negative regulator of T-cell responses. CD152 is a single pass type 1 transmembrane protein belonging to the immunoglobulin superfamily containing a single domain in the extracellular region. CD152 along with CD28 binds to the co-stimulatory molecules CD80 and CD86. Is able to block ligand binding on the Raji B-cell line and blocks binding of an alternative clone, BNI8 to CTLA-4/Ig in ELISA. Further studies indicate that clone BNI3 binds to the same epitope as classified anti CTLA-4 clones 11D4 and 10A8 (Wang et al. In: Leukocyte typing VI 1997 Garland Publishing Inc. pp97-98,. The cytoplasmic domain of CD152 contains a critical tyrosine at residue 201 phosphorylated by Janus Kinase 2 which subsequently controls surface expression through regulation of CD152 interaction with AP-2. CD152 is expressed primarily as an intracellular antigen with transport to the cell surface under tight regulation of several molecules including Trim, PLD and TIRC7, CD152 also demonstrates rapid internalization once expressed at the cell surface. CD152 plays a significant role in maintaining tolerance to self antigens and defects in CD152 presentation and expression has been implicated in a number of autoimmune diseases.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 20 ul of the suggested working dilution to label 5x10^5 cells in 100 ul. Method sheets are available on request.

Packaging

PBS, 0.1% sodium azide, 2% BSA.
Store at 2°C to 8°C degrees. Do not freeze.
For research use only.

About CTLA4 / CD152

P16410 NM_005214 NP_005205.2

CTLA4 Antibody, CD152 Antibody, CELIAC3 Antibody, CD152 antigen Antibody, CTLA-4 Antibody, Celiac disease 3 Antibody, IDDM12 Antibody, GRD4 Antibody, GSE Antibody, CD152 isoform Antibody

CTLA4 / CD152 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer.

Requested From: United States
Date Requested: 12/8/2016

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