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Anti-CTLA4 / CD152 Antibody (clone 1B8, Low Endotoxin) LS-C188473


Wt. Vol. Conc. Price
500 µg - 1 mg/ml $435
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular CTLA4 / CD152 Antibodies

Anti-CTLA4 / CD152 Antibody (clone A3.4H2.H12, FITC) LS-C62860
Mouse Monoclonal [clone A3.4H2.H12] (IgG2a,k) to Human CTLA4 / CD152
Flow Cytometry
FITC Conjugated
Anti-CTLA4 / CD152 Antibody (aa50-78) LS-C165112
Rabbit Polyclonal to Human CTLA4 / CD152
IHC - Paraffin, Western blot
Immunohistochemistry Image
Anti-CTLA4 / CD152 Antibody (clone KT56) LS-C193495
Mouse Monoclonal [clone KT56] (IgG1) to Human CTLA4 / CD152
Western blot, ELISA

100% Guaranteed 100% Guaranteed
Hamster Monoclonal [clone 1B8] (IgG) to Mouse CTLA4 / CD152
Immunofluorescence, Western blot, Immunoprecipitation, Flow Cytometry, ELISA (applications tested for the base form of this product only)
Unconjugated, Low Endotoxin


Mouse CTLA4 / CD152
Mouse (tested or 100% immunogen sequence identity)
IgG Monoclonal [1B8]
Protein G purified
Low Endotoxin


  • Immunofluorescence
  • Western blot
  • Immunoprecipitation
  • Flow Cytometry (1:10 - 1:100)
  • (applications tested for the base form of this product only)

Specificity and Use

CTLA4 / CD152 antibody was raised against extracellular portion of mouse CD152 fused to a mouse IgG2a.
Recognizes mouse CD152, commonly known as CTLA-4 (cytotoxic T-lymphocyte protein 4), a structural homolog for CD28. CD152 binds the same ligands as CD28, namely CD80 (B7.1) and CD86 (B7.2), but with much higher affinity. However, while binding of CD28 enhances T cell function, binding of CD152 inhibits it. CD152 is not detected on naive T-cells and is induced upon T-cell activation. In mice, lack of CD152 leads to massive lymphoproliferative disorder leading to tissue destruction and autoimmunity, suggesting a critical role for CD152 in limiting T-cell responses. CD152 has been shown to reduce IL-2 production after ligation and can inhibit T-cell expansion. This regulatory role and the high binding affinity of CD152 make it a potential therapy for autoimmune diseases such as rheumatoid arthritis. Clone 1B8 may be used to enhance proliferation and pro-inflammatory cytokines of lymph node cells. It may also be used to enhance tumor immunity.
The applications listed have been tested for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested.


Store at -20°C. Minimize freezing and thawing.
For research use only.

About CTLA4 / CD152

P16410 NM_005214 NP_005205.2

CTLA4 Antibody, CD152 Antibody, CELIAC3 Antibody, CD152 antigen Antibody, CTLA-4 Antibody, Celiac disease 3 Antibody, IDDM12 Antibody, GRD4 Antibody, GSE Antibody, CD152 isoform Antibody

CTLA4 / CD152 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer.

Requested From: United States
Date Requested: 10/26/2016

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