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Anti-CSF1R / CD115 / FMS Antibody (Extracellular Domain) LS-C6868

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Wt. Vol. Conc. Price
- 200 µl - $465
Inquire for larger quantities

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Rabbit Polyclonal (IgG) to Mouse CSF1R / CD115 / FMS
Mouse
ICC, Western blot, Immunoprecipitation, Flow Cytometry
Unconjugated

Details

Mouse CSF1R / CD115 / FMS
Rabbit
Mouse (tested or 100% immunogen sequence identity)
IgG Polyclonal
Antiserum

Applications

ICC (1:200 - 1:500), Western blot (1:500 - 1:1000), Immunoprecipitation (1:100), Flow Cytometry

Specificity and Use

CSF1R / CD115 / FMS antibody was raised against c-Fms obtained from Rab9 rabbit skin fibroblast cells transfected with a fully activated (transforming) murine Fms gene.
Extracellular Domain
Recognizes the extracellular domain of mouse c-fms encoded protein (also known as CSF-1R or M-CSF receptor) at 150kD and 165kD. Lower molecular weight degradation products may also be detected. Does not recognize human Fms.
Suitable for use in Western Blot, Immunoprecipitation, Immunocytochemistry and FACS. Proteins were visualized using a goat anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Immunoprecipitation: 1:100 precipitates p150 and p165 Fms from 35S-methionine labeled FDC-P1/MAC11 cell lysates. Immunocytochemistry: 1:200-1:500 detects Fms in FDC-P1/MAC11 cells fixed with 95% ethanol/5% acetic acid. Fluorescence-Activated Cell Sorting: 1:200 (reported by an independent laboratory).

Packaging

Supplied as a liquid.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
For research use only.

About CSF1R / CD115 / FMS

P07333 NM_005211 NP_005202.2

CSF1R Antibody, CD115 antigen Antibody, CSF-1R Antibody, CSF-1-R Antibody, CSF-1 receptor Antibody, FMS Antibody, Fim-2 Antibody, FIM2 Antibody, FMS proto-oncogene Antibody, M-CSFR Antibody, HDLS Antibody, M-cfs receptor Antibody, C-FMS Antibody, CD115 Antibody, CSF1 receptor Antibody, CSFR Antibody, M-CSF-R Antibody, MCSF Receptor Antibody, Proto-oncogene c-Fms Antibody

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes.

Requested From: United States
Date Requested: 9/30/2016

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