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Anti-CSA / ERCC8 Antibody (aa72-121) LS-C102730

Catalog	Size	Price
LS-C102730-50	50 µg	Unavailable

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Reactivity:	Human, Mouse
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Antibody:	Rabbit Polyclonal (IgG) to Human CSA / ERCC8
Reactivity:	Human, Mouse, Rat, Bovine, Dog, Horse, Rabbit
Application:	Western blot (applications tested for the base form of this product only)
Format:	Unconjugated

Details

Target:	Human CSA / ERCC8
Host:	Rabbit
Reactivity:	Human, Mouse, Rat, Bovine, Dog, Horse, Rabbit (tested or 100% immunogen sequence identity)
Predicted:	Monkey, Bat (at least 90% immunogen sequence identity)
Clonality:	IgG Polyclonal
Conjugations:	Unconjugated. Also available conjugated with Biotin, FITC, HRP.
Purification:	Immunoaffinity purified
Modifications:	Unmodified

Applications

Approved:

Western blot (0.2 - 1 µg/ml)
(applications tested for the base form of this product only)

Specificity and Use

Immunogen:

CSA / ERCC8 antibody was raised against synthetic peptide located between aa72-121 of human ERCC8 (B2RB64, NP_000073). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey (100%); Galago (92%); Marmoset, Bat (90%); Mouse, Rat, Hamster, Elephant, Panda, Dog, Bovine, Rabbit, Horse, Pig, Opossum, Guinea pig (85%).

Blocking Peptide:

LS-E21196 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C102730. Useful for pre-absorption and neutralization of the antibody's antigen binding site.

Epitope:

aa72-121

Specificity:

Human ERCC8

Usage:

Western Blot: Suggested dilution at 1µg/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as second antibody. ELISA titer in peptide based assay: 1:62500.

Packaging

Presentation:	Lyophilized from PBS with 2% sucrose
Reconstitution:	Distilled water
Storage:	Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than one week): +4°C. Avoid repeat freeze-thaw cycles.
Restrictions:	For research use only.

About CSA / ERCC8

Uniprot: Q13216 NCBI: NM_000082 NP_000073.1

Synonyms: ERCC8 Antibody, CKN1 Antibody, UVSS2 Antibody, CSA Antibody

Description: Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair.

(More About CSA / ERCC8)

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Western blot

ERCC8 antibody LS-C102730 Western blot of Placenta lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Requested From:
Date Requested: 6/28/2017

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