Human CRYAB / Alpha B Crystallin

Mouse

Human (tested or 100% immunogen sequence identity)

IgG2b Monoclonal

2E8

Unconjugated

Protein G purified

Unmodified

Recombinant human alpha B crystallin (1-175aa) purified from E. coli.

aa1-175

Recognizes alpha B crystallin, a 20kD water-soluble major structural protein and member of the heat shock protein family, designated HSPB5, which acts as a molecular chaperone and is believed to play a role in the maintenance of ocular lens transparency/refractive index. Besides the involvement of both alpha A and alpha B crystallin in the prevention of protein precipitation and cataract formation in the eye, alpha crystallins have also been demonstrated in other tissues including the heart, brain, kidney, spleen and thymus. Studies have shown that a mutation in alpha B crystallin is responsible for desmin-related myopathy (DRM) and cataract(1), and that alpha B crystallin is a major component of the astrocytic inclusions known as Rosenthal fibers (RFs), found in Alexander's disease.

• Western blot (1:1000 - 1:2000)
• ELISA

Western Blot: LS-C45027 detects a band of approximately 20kD in mouse eye cell lysates.

PBS, 0.02% Sodium Azide, 10% Glycerol

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P02511 NCBI: NM_001885 NP_001876.1