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CRYAA / Alpha A Crystallin

crystallin, alpha A

Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).

Gene Name: crystallin, alpha A
Synonyms: CRYAA, Alpha-crystallin A chain, Crystallin, alpha A, CRYA1, Crystallin, alpha-1, Heat shock protein beta-4, HSPB4
Target Sequences: NM_000394 NP_000385.1 P02489

☰ Filters
Antibodies (38)
Proteins (9)
ELISA Kits (8)
Custom (7)
Over-Expression Lysate (2)
Primary (38)
Recombinant (6)
Sandwich (1)
CRYAA / Alpha A Crystallin (55)
Human (39)
Mouse (18)
Rat (18)
Bovine (12)
Chicken (1)
Dog (1)
Pig (1)
Zebrafish (2)
IHC (9)
IHC-P (4)
WB (34)
ELISA (21)
IF (5)
Peptide-ELISA (1)
rabbit (19)
mouse (19)
IgG (15)
IgG1 (15)
IgG2b (4)
monoclonal mc (19)
polyclonal pc (19)
1H3.B8 (11)
c9F2 (1)
C9F2 (1)
OTI2C3 (2)
OTI2H2 (2)
OTI3B12 (2)
96-Well Strip Plate (8)
AP Conjugated (1)
APC Conjugated (2)
Atto 390 Conjugated (1)
Atto 488 Conjugated (1)
Atto 594 Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
Carrier-free (3)
FITC Conjugated (3)
HRP Conjugated (2)
PE Conjugated (1)
PerCP Conjugated (1)
RPE Conjugated (1)
Unconjugated (21)
aa77-106 (7)
No (55)
Plasma (1)
Serum (1)
Tissue Homogenates (1)
6His, C-terminus (2)
GST (1)
His, N-Terminal (1)
Myc-DDK (Flag) (3)
Human (8)
293T Cells (1)
E. coli (5)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (2)
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CRYAA / Alpha A Crystallin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
CRYAA / Alpha A Crystallin Antibody - IHC of paraffin-embedded Human breast tissue using anti-CRYAA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (OTI3B12) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
CRYAA / Alpha A Crystallin Antibody - IHC of paraffin-embedded Human breast tissue using anti-CRYAA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (Carrier-free) (OTI3B12) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CRYAA / Alpha A Crystallin Antibody - Immunohistochemistry of paraffin-embedded rat kidney tissue.
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CRYAA / Alpha A Crystallin Rabbit anti-Human Polyclonal Antibody
Zebrafish, Rat, Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CRYAA / Alpha A Crystallin Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-CRYAA mouse monoclonal antibody.
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CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (OTI2C3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
CRYAA / Alpha A Crystallin Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-CRYAA mouse monoclonal antibody.
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CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (Carrier-free) (OTI2C3) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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CRYAA / Alpha A Crystallin Rabbit anti-Human Polyclonal Antibody
Zebrafish, Rat, Mouse, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
CRYAA / Alpha A Crystallin Antibody - Alpha A Crystallin was detected in paraffin-embedded sections of mouse spleen tissues using rabbit anti- Alpha A Crystallin Antigen Affinity purified polyclonal antibody
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CRYAA / Alpha A Crystallin Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CRYAA / Alpha A Crystallin Antibody
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CRYAA / Alpha A Crystallin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
CRYAA / Alpha A Crystallin Antibody - Immunofluorescence staining of HepG2 cells at a dilution of 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4 °C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L) .
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CRYAA / Alpha A Crystallin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
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CRYAA / Alpha A Crystallin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (c9F2) Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$522
CRYAA / Alpha A Crystallin Antibody - Rat eye extracts were resolved by electrophoresis, transferred to PVDF membrane and probed with anti-crystallin a?(1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a DAP detection system. Arrow indicates crystalline a?(~20 kD). This antibody is not shown cross-activity.
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CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (C9F2) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$303; 100 µl/$365
CRYAA / Alpha A Crystallin Antibody - Alpha A Crystallin (1H3. B8), AlphaA (L) and AlphaB (R) crystallin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (1H3.B8) Antibody
Mouse, Bovine, Rat, Human
ELISA, WB
Unconjugated
50 µg/$312; 200 µg/$417
CRYAA / Alpha A Crystallin Antibody - Alpha A Crystallin (1H3. B8), AlphaA (L) and AlphaB (R) crystallin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (Biotin) (1H3.B8) Antibody
Mouse, Bovine, Rat, Human
ELISA, WB
Biotin Conjugated
200 µg/$479
CRYAA / Alpha A Crystallin Antibody - Alpha A Crystallin (1H3. B8), AlphaA (L) and AlphaB (R) crystallin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (FITC) (1H3.B8) Antibody
Mouse, Bovine, Rat, Human
ELISA, WB
FITC Conjugated
200 µg/$474
CRYAA / Alpha A Crystallin Antibody - Alpha A Crystallin (1H3. B8), AlphaA (L) and AlphaB (R) crystallin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (Atto 488) (1H3.B8) Antibody
Mouse, Bovine, Rat, Human
ELISA, WB
Atto 488 Conjugated
200 µg/$486
CRYAA / Alpha A Crystallin Antibody - Alpha A Crystallin (1H3. B8), AlphaA (L) and AlphaB (R) crystallin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (Atto 390) (1H3.B8) Antibody
Mouse, Bovine, Rat, Human
ELISA, WB
Atto 390 Conjugated
200 µg/$488
CRYAA / Alpha A Crystallin Antibody - Alpha A Crystallin (1H3. B8), AlphaA (L) and AlphaB (R) crystallin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (Atto 594) (1H3.B8) Antibody
Mouse, Bovine, Rat, Human
ELISA, WB
Atto 594 Conjugated
200 µg/$486
CRYAA / Alpha A Crystallin Antibody - Alpha A Crystallin (1H3. B8), AlphaA (L) and AlphaB (R) crystallin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (AP) (1H3.B8) Antibody
Mouse, Bovine, Rat, Human
ELISA, WB
AP Conjugated
200 µg/$478
CRYAA / Alpha A Crystallin Antibody - Alpha A Crystallin (1H3. B8), AlphaA (L) and AlphaB (R) crystallin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (APC) (1H3.B8) Antibody
Mouse, Bovine, Rat, Human
ELISA, WB
APC Conjugated
200 µg/$486
CRYAA / Alpha A Crystallin Antibody - Alpha A Crystallin (1H3. B8), AlphaA (L) and AlphaB (R) crystallin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (PerCP) (1H3.B8) Antibody
Mouse, Bovine, Rat, Human
ELISA, WB
PerCP Conjugated
200 µg/$486
CRYAA / Alpha A Crystallin Antibody - Alpha A Crystallin (1H3. B8), AlphaA (L) and AlphaB (R) crystallin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CRYAA / Alpha A Crystallin Mouse anti-Human Monoclonal (RPE) (1H3.B8) Antibody
Mouse, Bovine, Rat, Human
ELISA, WB
RPE Conjugated
200 µg/$481
Select
CRYAA / Alpha A Crystallin Rabbit anti-Human Polyclonal (aa77-106) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
CRYAA / Alpha A Crystallin Mouse Monoclonal (1H3.B8) Antibody
Mouse, Bovine, Rat, Human
ELISA, WB
Unconjugated
100 µg/$480
Viewing 1-25 of 55 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).