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CREB1 / CREB
cAMP responsive element binding protein 1
CREB (cAMP response element binding protein1), a DNA binding protein, is a member of the leucine zipper family of transcription factors. CREB interaction with DNA requires phosphorylation at Ser 119 by activated cAMP protein kinase A. Once phosphorylated CREB binds to an 8 base enhancer know as the cAMP response element (CRE) containing a conserved core sequence TGACG. CREB also interacts with CBP (CREB binding protein) and RNA polymerase II when phosphorylated on Ser 133. Different isoforms of this protein are the result of two transcript variants.
| Gene Name: | cAMP responsive element binding protein 1 |
| Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
| Synonyms: | CREB1, CREB-1, Transactivator protein, CREB |
| Target Sequences: | NM_134442 NP_004370.1 P16220 |
Publications (8)
1
Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress. Shi Y, Venkataraman SL, Dodson GE, Mabb AM, LeBlanc S, Tibbetts RS. Proceedings of the National Academy of Sciences of the United States of America. 2004 101:5898-903.
[PubMed:15073328]
[PMC:PMC395895]
2
Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo. Shi Y, Dodson GE, Shaikh S, Rundell K, Tibbetts RS. The Journal of biological chemistry. 2005 280:40195-200.
[PubMed:16221684]
3
DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM. Dodson GE, Tibbetts RS. The Journal of biological chemistry. 2006 281:1692-7.
[PubMed:16293623]
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CREB1 / CREB Rabbit anti-Human Polyclonal (pSer142) Antibody
Chicken, Zebrafish, Pig, Bovine, Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
Wheat Germ Extract
GST
63.25 kDa
2 µg/$439
CREB1 / CREB Rabbit anti-Human Monoclonal Antibody
Drosophila, Rat, Mouse, Human, Monkey
Flo, IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µl/$589
CREB1 / CREB Mouse anti-Human Monoclonal (5G3) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$459
CREB1 / CREB Rabbit anti-Human Monoclonal (pSer133) (AF488) Antibody
Mouse, Human
ELISA, Flo, ICC, IF, IHC, IHC-Fr
AF488 Conjugated
100 µl/$675
CREB1 / CREB Mouse anti-Human Monoclonal (3F1-1B2) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CREB1 / CREB Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Zebrafish, Pig, Bovine, Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
E. coli
6His, N-terminus
40.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CREB1 / CREB Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
Flo, IF, IHC, IP, WB
Unconjugated
20 µl/$299; 50 µl/$341; 100 µl/$431; 200 µl/$539
CREB1 / CREB Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
CREB1 / CREB Rabbit anti-Human Polyclonal (aa251-300) Antibody
Human
WB
Unconjugated
100 µl/$424
CREB1 / CREB Rabbit anti-Human Polyclonal (aa251-300) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Orangutan, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
CREB1 / CREB Rabbit anti-Rat Polyclonal (pSer133) Antibody
Xenopus, Chicken, Bovine, Mouse, Dog, Rat, Human
WB
Unconjugated
100 µl/$469
CREB1 / CREB Goat anti-Human Polyclonal (aa96-109) Antibody
Mouse, Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CREB1 / CREB Rabbit anti-Human Polyclonal (pSer133) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$391
CREB1 / CREB Mouse anti-Human Monoclonal (5F2) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CREB1 / CREB Rabbit anti-Human Polyclonal (aa250-300) Antibody
Mouse, Human
IF, IHC
Unconjugated
2.5 µg/$295; 100 µl/$532
CREB1 / CREB Rabbit anti-Rat Polyclonal (pSer133) Antibody
Xenopus, Zebrafish, Pig, Rat, Mouse, Dog, Bovine, Human
GS, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$842
CREB1 / CREB Rabbit anti-Human Polyclonal (pSer121) Antibody
Chicken, Zebrafish, Pig, Mouse, Rat, Sheep, Bovine, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$315
CREB1 / CREB Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
100 µl/$332
CREB1 / CREB Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, GS, WB
Unconjugated
100 µl/$567
CREB1 / CREB Rabbit anti-Human Polyclonal (pSer142) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CREB1 / CREB Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
CREB1 / CREB Rabbit anti-Human Polyclonal (aa91-140) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
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