Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 5G3] (IgG1) to Human CREB1 / CREB
Human, Monkey, Mouse, Rat
IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Mouse Monoclonal (IgG1) to Human CREB1 / CREB
Western blot, ELISA
Human CREB1 / CREB
Human (tested or 100% immunogen sequence identity)
Western blot (2 - 4 µg/ml)
Specificity and Use
CREB1 / CREB antibody was raised against synthetic peptide of human CREB.
Recognizes human CREB (cAMP Response Element Binding Protein, Biotin).
Suitable for detection of CREB by Western blot. A protein of 43kD can be detected in HeLa cells. It is also suitable for ELISA. Western blot: 2-4 ug/ml. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
PBS, 0.02% sodium azide.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C.
CREB1 Antibody, CREB-1 Antibody, Transactivator protein Antibody, CREB Antibody
CREB (cAMP response element binding protein1), a DNA binding protein, is a member of the leucine zipper family of transcription factors. CREB interaction with DNA requires phosphorylation at Ser 119 by activated cAMP protein kinase A. Once phosphorylated CREB binds to an 8 base enhancer know as the cAMP response element (CRE) containing a conserved core sequence TGACG. CREB also interacts with CBP (CREB binding protein) and RNA polymerase II when phosphorylated on Ser 133.