Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
IHC - Paraffin
IHC - Frozen
Specificity and Use
Recognizes human CD35.
Flow cytometry. Immunohistochemistry (frozen sections and paraffin section). Western blotting. Immunoprecipitation. Flow Cytometry: 10 ul/1E6 cells. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
CR1 Antibody, C3b/C4b receptor Antibody, C3-binding protein Antibody, CD35 Antibody, C3BR Antibody, Knops blood group antigen Antibody, C4BR Antibody, CD35 antigen Antibody, Complement receptor type 1 Antibody, KN Antibody
CR1 / CD35 is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement.