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COX8A is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits.
Gene Name: | cytochrome c oxidase subunit VIIIA (ubiquitous) |
Synonyms: | COX8A, COX8L, COX8-2, COX, COX8, VIII, VIII-L |
Target Sequences: | NM_004074 NP_004065.1 P10176 |
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