Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
SPRR1B Antibody, 14.9 kd pancornulin Antibody, 14.9 kDa pancornulin Antibody, CORNIFIN Antibody, GADD33 Antibody, SPR-IB Antibody, Small proline-rich protein IB Antibody, SPRR1 Antibody, Cornifin B Antibody, Cornifin-B Antibody, Small proline-rich protein 1B Antibody
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.
Formalin-fixed and paraffin-embedded human breast carcinoma reacted with SPRR1B Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of SPRR1B Antibody in MDA-MB231, MDA-MB435 cell line lysates (35 ug/lane). SPRR1B (arrow) was detected using the purified antibody.