Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Western blot (1 - 3 µg/ml)
Specificity and Use
Synthetic peptide C-QVGNGSALPTNDNS from an internal region of human Corneodesmosin / CDSN (NP_001255.3). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon (100%); Rat (71%).
Human Corneodesmosin / CDSN
Peptide ELISA: antibody detection limit dilution 1:1000. Western blot: Approx 50kD band observed in lysates of cell line A431 (calculated MW of 51.6kD according to NP_001255.3). Recommended concentration: 1-3 ug/ml.
CDSN Antibody, D6S586E Antibody, HTSS1 Antibody, HTSS Antibody, S protein Antibody, Corneodesmosin Antibody, PSS Antibody
Corneodesmosin / CDSN is a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.