COMT

catechol-O-methyltransferase

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

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Antibodies (70)

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COMT (94)

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IHC-plus™ COMT Antibody (Internal) LS-A8834

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(4.0) Rating

Antibody:

COMT Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ COMT Antibody (aa170-183) LS-B4343

(5.0) Rating

(1) Publication(s)

Antibody:

COMT Goat anti-Human Polyclonal (aa170-183) Antibody

Reactivity:

Bovine, Pig, Horse, Human, Monkey

Applications:

ELISA, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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IHC-plus™ COMT Antibody (aa52-65) LS-B4880

(4.0) Rating

Antibody:

COMT Goat anti-Human Polyclonal (aa52-65) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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Human COMT (Sandwich ELISA) ELISA Kit - LS-F13132

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human COMT (Sandwich ELISA) ELISA Kit - LS-F6763

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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IHC-plus™ COMT Antibody (Internal) LS-A8833

Fast Shipping

(4.0) Rating

Antibody:

COMT Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Bovine, Rat, Pig, Bat, Human, Monkey

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ COMT Antibody (C-Terminus) LS-A8836

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(4.0) Rating

Antibody:

COMT Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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Rat COMT Protein (Recombinant His) (aa63-264) - LS-G16026

Source:

E. coli

Tag:

His

Molecular Weight:

24.0 kDa

Price:

10 µg/$283; 50 µg/$452; 200 µg/$902; 1 mg/$2,016; 5 mg/$3,151; 2 mg/$2,204

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COMT Antibody (Internal) LS-C352043

Antibody:

COMT Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$299

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COMT Antibody LS-C664700

Antibody:

COMT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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COMT Antibody LS-C490215

Antibody:

COMT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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COMT Antibody (aa52-271) LS-C407752

Antibody:

COMT Rabbit anti-Human Polyclonal (aa52-271) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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COMT Antibody LS-C334555

Antibody:

COMT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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Human COMT Protein (Recombinant His) (aa52-271) - LS-G16024

Source:

E. coli

Tag:

His

Molecular Weight:

25.8 kDa

Price:

10 µg/$275; 50 µg/$402; 200 µg/$802; 1 mg/$1,876; 5 mg/$2,838; 2 mg/$2,060

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Human COMT Protein (Recombinant) - LS-G3376

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$511; 500 µg/$1,348; 20 µg/$311

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IHC-plus™ COMT Antibody (N-Terminus) LS-A8831

Fast Shipping

(4.0) Rating

Antibody:

COMT Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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COMT Antibody LS-C830464

Antibody:

COMT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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IHC-plus™ COMT Antibody (Internal) LS-A9769

Fast Shipping

(4.0) Rating

Antibody:

COMT Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ COMT Antibody (Internal) LS-A9797

Fast Shipping

(4.0) Rating

Antibody:

COMT Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

Select

COMT Antibody (aa94-108) LS-C313303

Antibody:

COMT Rabbit anti-Human Polyclonal (aa94-108) Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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COMT Antibody (30-110 aa, Internal) LS-C382850

Antibody:

COMT Rabbit anti-Human Polyclonal (30-110 aa, Internal) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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COMT Antibody LS-C830481

Antibody:

COMT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

COMT Antibody (clone 1G4-1A1) LS-C196950

Antibody:

COMT Mouse anti-Human Monoclonal (1G4-1A1) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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COMT Antibody (aa221-271) LS-C290293

Antibody:

COMT Rabbit anti-Human Polyclonal (aa221-271) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

COMT Antibody LS-C804918

Antibody:

COMT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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