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Anti-Complement C3c Antibody (HRP) LS-C147218

Ordering

Wt. Vol. Conc. Price
- 1000 µl - $345
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Most Popular Complement C3c Antibodies

Anti-Complement C3c Antibody (FITC) LS-C42306
Sheep Polyclonal (IgG) to Human Complement C3c
Human
IHC - Paraffin, IHC - Frozen, ELISA
FITC Conjugated
Immunohistochemistry Image
Anti-Complement C3c Antibody IHC-plus™ LS-B7932
Rabbit Polyclonal to Human Complement C3c
Human
IHC - Paraffin, Immunodiffusion
Unconjugated
Immunohistochemistry Image
Anti-Complement C3c Antibody (FITC) LS-C185015
Goat Polyclonal (IgG) to Rabbit Complement C3c
Rabbit
ELISA, Immunoelectrophoresis
FITC Conjugated

100% Guaranteed 100% Guaranteed
Goat Polyclonal to Human Complement C3c
Human
IHC, Western blot, ELISA
HRP Conjugated

Details

Human Complement C3c
Goat
Human (tested or 100% immunogen sequence identity)
Polyclonal
Horseradish Peroxidase
Purified IgG
Unmodified

Applications

  • IHC
  • Western blot
  • ELISA

Specificity and Use

Complement C3c antibody was raised against human C3c
Human Complement C3c. In immunoelectrophoresis against fresh human serum, a single precipitin line is obtained in the beta-1 region representing native C3. Against serum containing partly activated C3, a precipitin line is obtained which extends from the beta-1 into the alpha-2 region, demonstrating a gradient. In old serum containing totally activated C3 a single precipitin line in the alpha-2 region is obtained. Antisera to C3c can also react with the fragments C3b, C3bi and smaller fragments, since they all carry antigenic determinants of the C3c domain. The product does not react with any other proteins component of human serum or plasma. Cross-reactivity The antiserum does not cross-react with any other component of human plasma. Inter-species cross-reactivity is a normal feature of antibodies to plasma proteins since they frequently share antigenic determinants. Cross-reactivity of this antiserum has not been tested in detail.
This product is intended for use in enzyme-immunocytochemical and histochemical staining of human C3c in appropriately prepared substrates at the cellular and subcellular level. Locally deposited immune complexes in tissue usually contain complement, pointing to activation of the classical pathway. Complement activation in vivo implies active disease and may contribute to the elicitation of the pathogenesis and he extent of tissue destruction. In ELISA and Western blotting to identify human C3c in serum or other body fluids. This immunoconjugate is not pre-diluted. The optimum working dilution of each conjugate should be established by titration before being used. Excess labeled antibody must be avoided because it may cause high unspecific background staining and interfere with the specific signal. Working dilutions for histochemical and cytochemical use are usually between 1:100 and 1:500; In ELISA and comparable non-precipitating antibody-binding assays between 1:1000 and 1:7000. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Packaging

Lyophilized from PBS, pH 7.2
1,000 µl Sterile distilled water 1 ml
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About Complement C3c

C3c is the major fragment resulting from the C3 cleavage by C3 convertase and factor i. It is composed of an intact beta chain bound to two fragments of the alpha chain.

Requested From: United States
Date Requested: 12/3/2016

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