Human Complement C3
(tested or 100% immunogen sequence identity)
Protein A purified
- Western blot
- ELISA (1:1500 - 1:6000)
Complement C3 antibody was raised against native purified human C3a.
Recognizes 9 kD complement component 3a (C3a) which is present in the blood serum. C3a is generated over the course of complement activation where complement 3 (C3) convertases cleave C3 to C3a and C3b, which is further degraded into iC3b and C3dg/C3d. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation. C3a mediates local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3a is expressed at significantly higher levels in colorectal cancer. Shows minimal reactivity with other complement proteins in radioimmunoassays and hemagglutination. Clone 10-21 has been reported to work in western blotting applications.
Borate buffered saline, pH 8.2, 0.02% sodium azide.
For research use only.
This antibody carries the LSBio 100% Guarantee.