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Anti-Complement C3 / C3b Antibody (clone 013III-1.16) LS-C44976


Wt. Vol. Conc. Price
100 µg - 1 mg/ml Unavailable

Most Popular Complement C3 / C3b Antibodies

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Anti-Complement C3 / C3b Antibody (clone 013III-1.16) LS-C44976
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Anti-Complement C3 / C3b Antibody LS-C191523
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100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 013III-1.16] (IgG2b) to Human Complement C3 / C3b
IHC - Frozen, Western blot, Flow Cytometry, ELISA


Human Complement C3 / C3b
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [013III-1.16]
Protein A purified


  • IHC - Frozen
  • Western blot
  • Flow Cytometry

Specificity and Use

Purified human iC3b.
Recognizes 42kD human inactive complement component 3b (iC3b) neoantigen present in blood serum. Cleavage of C3b into iC3b by the protease factor I, in the presence of cofactors, changes the structure and resulting binding properties, preventing binding by complement factor B and properdin. This prevents further progression of the complement pathway, providing another mechanism by which the complement pathway may be regulated. iC3b is thought to play a role in inducing tolerance, binding complement receptor type 3 on antigen presenting cells and stimulating them to produce transforming growth factor beta2 and interleukin-10. It is thought to stimulate B-cells via the CD21 receptor providing a link between the innate and adaptive immune responses. Additionally iC3b acts as an opsonin which is recognized by complement receptor 3 expressed on leukocytes or complement receptor of the immunoglobulin superfamily (CRIg) on Kupffer cells, stimulating phagocytosis of the tagged cells. iC3b levels are often elevated in diseases such as Systemic Lupus Erythematosus and Rheumatoid arthritis.


Borate buffered saline, pH 8.2 - 8.4, 0.02% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About Complement C3 / C3b

Complement C3b is the larger of two elements formed by the cleavage of complement component 3. C3b covalently bonds to microbial cell surfaces within an organism's body. This leads to the production of surface-bound C3-convertase and thus more C3b components. Bound C3b also aids in opsonization of the microbe by macrophages. Complement receptor 1 (CR1) on macrophages allows the engaging of C3b covered microbes. C3b also aids in the clearance of immune complexes (antigen-antibody).

Requested From: 
Date Requested: 4/23/2017

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